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Dr. Frenkel Dan

מחלקה לנוירוביולוגיה סגל אקדמי בכיר
Dr. Frenkel Dan
Phone: 03-6409484
Fax: 03-6409028
Office: Sherman - Life Sciences, 424

Research Interests

Research area: Neuroimmunology, Neurodegenration.

 

Current Research Topics:  The role  of glia cells during central nervous system inflammation using models of stroke and Alzheimer's disease.

 

Methods & Techniques: Immunology, Cell biology, Molecular biology, Histology.

 

Although neurodegenerative diseases are not considered immune mediated, the nature of the immune response is crucial in the application of immunotherapeutic approaches.Resting glia cells are highly sensitive to changes in the tissue microenvironment. Activation is associated with increased production of potentially cytotoxic molecules, including reactive oxygen species (ROS), proteases, and pro-inflammatory cytokines, together with induction of phagocytosis. Their role however, is complex, and different subsets of glia cells can be neuroprotective or neurotoxic. The presence of recruited leukocytes at the site of inflammation is critically dependent upon the coordinated expression of adhesion molecules, ligands and receptors on inflammatory cells and the activated capillary endothelium, respectively. Modulation of neuroinflammation may have applicability both as a preventative therapy and as a treatment in stress and neurodegenerative diseases.

 

The research in the lab is focused on understanding glia-neuron interaction to further understand their role in neurological diseases both in culture and in vivo using models of stroke, Alzheimer's disease, and multiple sclerosis.

 

Recent Publications

Peer-review last three years

Hjorth E, Frenkel D, Weiner H, Schultzberg M. “Effects of immunomodulatory substances on phagocytosis of Abeta1-42 by human microglia” International Journal of Alzheimer's Disease, 2010, pii: 798424.

 

Levy H, Assaf Y, Frenkel D. Characterization of brain lesions in a mouse model of progressive multiple sclerosis. Exp Neurol. 2010 226(1):148-58.

 

Farfara D., Trudler D., Amzaleg-Segev  N., Galron R., Stein R., Frenkel D. Gamma-secretase component presenilin mediates microglia beta amyloid clearance. Ann Neurology, 2011, 69(1):170-80. doi: 10.1002/ana.22191.

 

Goldfarb Y, Levi B, Sorski L, Frenkel D, Ben-Eliyahu S “ CpG-C immunotherapeutic efficacy is jeopardized by ongoing exposure to stress: Potential implications for clinical use”Brain Behav Immun. 2011 25(1):67-76

 

Weiss  R. Lifshitz  V, Frenkel  D. TGF-β1 affects endothelial cell interaction with macrophage and Th1 T-cells leading to the development of cerebrovascular amyloidosis”Brain Behav Immun.2011 Jul;25(5):1017-24

 

Frydman-Marom A., Levin A., Farfara D., Benromano T., Scherzer-Attali1 R., Vassar R., Segal D., Gazit E., Frenkel D., and Ovadia M., “Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models” PloS One,  2011.6(1):e16564

 

Lifshitz V., Benromano T., Kfir E.,  Blumenfeld-Katzir T. , Tempel-Brami  C. Assaf   Y., Xia  W., Wyss-Coray  T., Weiner  HL, and Frenkel  D.. “Immunotherapy of cereberovascular amloidosis in a transgenic mouse model” , Neurobiology of aging, 2012  33(2):432.e1-432.e13

 

Galron R., Gruber R. Kirshner M. Ziv  N. Wang  ZO. Shiloh Y. Barzilai A., and Frenkel D.  Glial cells Dysfunction enhanced Neurotoxicity in Nijmegen Breakage Syndrome Animal Model, JMN 2011 45(2):202-11

 

Raz-Prag D., Galron R., Segev-Amzaleg N., Barzilai A., Shiloh Y., and Frenkel D. ”A role for vascular deficiency  in retinal pathology in a mouse model of ataxia-telangiectasia” , The American Journal of Pathology,Am J Pathol. 2011 ;179(3):1533-41.

 

Scherzer-Attali R., Farfara D. , Cooper I., Levin A., Ben-Romano T., Trudler D.,Vientrov M., Shaltiel-Karyo R., Shalev D.E., Segev-Amzaleg N., Gazit E., Segal D. Frenkel D. Naphthoquinone-tyrptophan reduces neurotoxic Abeta*56 levels and improves cognition in Alzheimer's disease animal model, Neurobiol Dis. 2012 ;46(3):663-72.

 

Adler-Abramovich L, Vaks L, Carny O, Trudler D, Magno A, Caflisch A, Frenkel D, Gazit E. Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria.” Nat Chem Biol. 2012.8(8):701-6doi: 10.1038/nchembio.1002.4

 

Levy-Barazany H. , Frenkel D. “Expression of Scavenger receptor A on antigen presenting cells is important for CD4+T-cells proliferation in EAE mouse model.” Journal of Neuroinflammation 2012, 9:120doi: 10.1186/1742-2094-9-120.

 

Meshulam L, Galron R, Kanner S, De Pittà M, Bonifazi P, Goldin M, Frenkel D, Ben-Jacob E, Barzilai .” The role of the neuro-astro-vascular unit in the etiology of ataxia telangiectasia.“FrontPharmacol. 2012;3:157.

 

Kirshner M, Galron R, Frenkel D, Mandelbaum G, Shiloh Y, Wang ZQ, BarzilaiA.”Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain.” J MolNeurosci. 2012, 46(3):554-68.

 

Avrahami L, Farfara D, Shaham-Kol M, Vassar R, Frenkel D, Eldar-Finkelman H. Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model: IN VIVO AND IN VITRO STUDIES. J Biol Chem. 2013;288(2):1295-306.

 

Lifshitz V, Weiss R, Levy H, Frenkel D. (2012) Scavenger Receptor A Deficiency Accelerates Cerebrovascular Amyloidosis in an Animal Model. 2013 J MolNeurosci2013 50:198-203.

 

Lifshitz V, Benromano T, Weiss R, Blanga-Kanfi S, Frenkel D.Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model.  Brain Behav Immun. 2013 30:143-149

 

Segev-Amzaleg N, Trudler D, Frenkel D.Preconditioning to mild oxidative stress mediates astroglialneuroprotection in an IL-10-dependent manner. Brain Behav Immun. 2013 30: 176-185

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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