Our lab studies the mechanisms of cancer cell reprogramming and the contributions of the tumor microenvironment to this process. Using an integrative approach to study brain tumor (glioma)-specific neurobiology and oncobiology, the research in my lab currently explores the following directions:
- Examining the parallel changes in oncogenesis and the induction of pluripotency
- Elucidating the mechanisms involved in cancer cell plasticity
- Understanding the molecular basis of tumor cell heterogeneity and the contribution of the tumor microenvironment
- Identifying the molecular events involved in gliomagenesis
- Designing novel therapeutic approaches combining adoptive immune gene therapy and nanotechnology
Our lab combines cell biology, molecular biology, biochemistry, immunology, cancer research, as well as advanced genome-wide techniques and microscopy.
To recapitulate human tumors in a mouse model, we use inducible-lentiviral vectors to introduce oncogenes/tumor suppressor genes in a cell-type and tissue specific manner.