Prof. Eran Bacharach

מח חקר התא ואימונולוגיה סגל אקדמי בכיר
Prof. Eran Bacharach
Phone: 03-6407692
Fax: 03-6422046
Office: Britannia-Porter, 404

Biography

Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the Hebrew University and conducted his postdoctoral research at the laboratory of Prof. Stephen P. Goff , Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University.

 

Research Interests

My research interests are:

  • Molecular virology
  • Replication of human and animal RNA viruses, including respiratory pathogens
  • Oncolytic viruses
  • Gene transfer with viral vectors
  • Analysis of virus-host interactions
  • Innate immune response to viral infections

Recent Publications

Selected Publications

 

Cell composition analysis of bulk genomics using single-cell data. Frishberg A, Peshes-Yaloz N, Cohn O, Rosentul D, Steuerman Y, Valadarsky L, Yankovitz G, Mandelboim M, Iraqi FA, Amit I, Mayo L, Bacharach E, Gat-Viks I. Nat Methods. 2019 Apr;16(4):327-332.

 

Predicting Phenotypic Diversity from Molecular and Genetic Data. Harel T, Peshes-Yaloz N, Bacharach E, Gat-Viks I. Genetics. 2019 Sep;213(1):297-311.

 

Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing. Steuerman Y, Cohen M, Peshes-Yaloz N, Valadarsky L, Cohn O, David E, Frishberg A, Mayo L, Bacharach E, Amit I, Gat-Viks I. Cell Syst. 2018 Jun 27;6(6):679-691.e4.

 

Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States. Danziger O, Pupko T, Bacharach E, Ehrlich M. Front Immunol. 2018 Jan 30;9:94.

 

NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection. Diab M, Glasner A, Isaacson B, Bar-On Y, Drori Y, Yamin R, Duev-Cohen A, Danziger O, Zamostiano R, Mandelboim M, Jonjic S, Bacharach E, Mandelboim O. Eur J Immunol. 2017 Apr;47(4):692-703.

 

Suppression of human metapneumovirus (HMPV) infection by the innate sensing gene CEACAM1. Diab M, Vitenshtein A, Drori Y, Yamin R, Danziger O, Zamostiano R, Mandelboim M, Bacharach E, Mandelboim O. Oncotarget. 2016 Oct 11;7(41):66468-66479.

 

Detection of Tilapia Lake Virus in Clinical Samples by Culturing and Nested Reverse Transcription-PCR. Kembou Tsofack JE, Zamostiano R, Watted S, Berkowitz A, Rosenbluth E, Mishra N, Briese T, Lipkin WI, Kabuusu RM, Ferguson H, Del Pozo J, Eldar A, Bacharach E. J Clin Microbiol. 2017 Mar;55(3):759-767.

 

Characterization of a Novel Orthomyxo-like Virus Causing Mass Die-Offs of Tilapia. Bacharach E, Mishra N, Briese T, Zody MC, Kembou Tsofack JE, Zamostiano R, Berkowitz A, Ng J, Nitido A, Corvelo A, Toussaint NC, Abel Nielsen SC, Hornig M, Del Pozo J, Bloom T, Ferguson H, Eldar A, Lipkin WI. mBio. 2016 Apr 5;7(2):e00431-16.

 

Targeting the Early Step of Building Block Organization in Viral Capsid Assembly. Lampel A, Bram Y, Ezer A, Shaltiel-Kario R, Saad JS, Bacharach E, Gazit E. ACS Chem Biol. 2015 Aug 21;10(8):1785-90.

 

Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection. Danziger O, Shai B, Sabo Y, Bacharach E, Ehrlich M. Oncotarget. 2016 Aug 9;7(32):52115-52134.

 

Identification of a novel RNA virus lethal to tilapia. Eyngor M, Zamostiano R, Kembou Tsofack JE, Berkowitz A, Bercovier H, Tinman S, Lev M, Hurvitz A, Galeotti M, Bacharach E, Eldar A. J Clin Microbiol. 2014 Dec;52(12):4137-46.

 

Dynamics and restriction of murine leukemia virus cores in mitotic and interphase cells. Elis E, Ehrlich M, Bacharach E. Retrovirology. 2015 Nov 14;12:95.

 

E. Elis , M. Ehrlich, A. Prizan-Ravid, N. Laham-Karam, E. Bacharach. p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes. PLoS Pathogens 2012 Dec 8, e1003103.

 

D. Nachmias,E.H. Sklan, M. Ehrlich, and E. Bacharach. Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway. Retrovirology. 2012 Vol. 9, pp. 1-7.

 

Sabo Y, Ehrlich M, Bacharach E. The conserved YAGL motif in the human metapneumovirus is required for higher ordered cellular assemblies of the matrix protein and for virion production. J. Virol. 2011 Apr 27. 85, pp. 6594–6609. 2011.

 

A. Prizan-Ravid , E. Elis , N. Laham-Karam , S. Selig , M. Ehrlich, E. Bacharach. The Gag Cleavage Product, p12, is a Functional Constituent of the Murine Leukemia Virus Pre-Integration Complex. PLoS Pathogens. 2010 Nov 11;6(11):e1001183.

 

C. Banet-Noach, L. Simanov, N. Laham-Karam, S. Perk, E. Bacharach. Longitudinal survey of avian metapneumoviruses in poultry in Israel: Infiltration of field strains into vaccinated flocks. Avian Diseases. 2009 Jun Vol. 53, No. 2, pp. 184–189.

 

Y. Sabo, N. Laham-Karam, E. Bacharach. Basal Budding and Replication of the Murine Leukemia Virus are Independent of the Gag L-Domains. J. Virol. 2008 Oct 82(19):9770-9775.

 

N. Laham, E. Bacharach. Transduction of human immunodeficiency virus type 1 (HIV-1) vectors lacking the encapsidation and dimerization signals. J. Virol. Vol. 81(19), 2007 (pp. 10687-98).

 

I. Mayrose, A. Doron-Faigenboim, E. Bacharach, T. Pupko. Towards realistic codon models: among site variability and dependency of synonymous and nonsynonymous rates. Bioinformatics. Vol. 23, 2007 (pp. i319-i327).

 

 A. Stern, A. Doron-Faigenboim, E. Erez, E. Martz, E. Bacharach, T. Pupko. Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach. Nucleic Acids Res. Vol. 35(Web Server issue), 2007 (pp. W506-11).

 

M. Mark-Danieli, N. Laham, M. Kenan-Eichler, A. Castiel, D. Melamed, M. Landau, N. M. Bouvier, M. J. Evans, E. Bacharach. Single point mutations in the zinc-finger motifs of HIV-1 nucleocapsid alter RNA-binding specificities of the Gag protein and enhance packaging and infectivity. J. Virol. Vol. 79(12), 2005 (pp.7756–7767).

 

D. Melamed, M. Mark-Danieli, M. Kenan-Eichler, O. Kraus, A. Castiel, N. Laham, T. Pupko, F. Glaser, N. Ben-Tal, E. Bacharach. The conserved carboxy-terminus of the human immunodeficiency virus type 1 capsid domain of the Gag protein is important for virion assembly and release. J. Virol. Vol. 78(18), 2004 (pp.9675–9688).  

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