Prof. Guido Sessa

ביולוגיה מול.ואקול.צמחים סגל אקדמי בכיר
Prof. Guido Sessa
Phone: 03-6409766
Fax: 03-6409380
Office: Britannia-Porter, 526

CV

Education

Period Degree Institute Faculty/Department
1998-2000 BARD Postdoctoral fellow Cornell University Dept. of Plant Pathology
1997-1998 BARD Postdoctoral fellow Purdue University Dept. of Agronomy
1991-1996 Ph.D. degree The Weizmann Institute of Science Dept. of Plant Genetics
1988-1991 M.Sc. degree The Weizmann Institute of Science Dept. of Plant Genetics
1985-1988 B.Sc. degree Hebrew University of Jerusalem Faculty of Agriculture

 

Employment

Period Rank/Function School/Department Institute
2018-present Head of the School School of Plant Sciences and Food Security Tel Aviv University
2013-present Full Professor School of Plant Sciences and Food Security Tel Aviv University
2010-2013 Associate Professor Dept. of Molecular Biology and Ecology of Plants Tel Aviv University
2006-2010 Senior Lecturer Dept. of Molecular Biology and Ecology of Plants Tel Aviv University
2000-2006 Lecturer Dept. of Plant Sciences Tel Aviv University

Research Interests

The main interest of my laboratory is to study of molecular mechanisms that govern plant immunity and susceptibility to bacterial pathogens. On the plant side, we use molecular biology, functional genomics and proteomics approaches to dissect recognition events and signal transduction pathways that mediate immunity. On the bacterial side, we apply genetic and biochemical strategies to unveil the mode of action of bacterial virulence factors that manipulate host functions. Our investigation has a direct impact on agriculture by providing targets and biotechnological strategies for the development of disease control against economically important pathogens.

Recent Publications

Since 2010:

 

Guerrero, I. J., F. Pérez-Montaño, G. M. da Silva, N. Wagner, D. Shkedy, M. Zhao, L. Pizarro, M. Bar, R. Walcott, G. Sessa, T. Pupko, and S. Burdman (2020). Show me your secret(ed) weapons: a multifaceted approach reveals a wide arsenal of type III-secreted effectors in the cucurbit pathogenic bacterium Acidovorax citrulli and novel effectors in the Acidovorax genus. Mol. Plant Pathol. 21: 17-37.

 

Nissan, G., L. Chalupowicz, G. Sessa, S. Manulis-Sasson and I. Barash (2019). Two Pantoea agglomerans type III effectors can transform nonpathogenic and phytopathogenic bacteria into host-specific gall-forming pathogens. Mol. Plant Pathol. 20: 1582-1587.

 

Majhi, B. B., and G. Sessa (2019). Overexpression of BSK5 in Arabidopsis thaliana provides enhanced disease resistance. Plant Signal. Behav. e1637665.

 

Roberts R., S.R. Hind, K. F. Pedley, B. A. Diner, M. J. Szarzanowicz, D. Luciano-Rosario, B. B. Majhi, G. Popov, G. Sessa, C. S. Oh and G. B. Martin (2019). Mai1 protein acts between host recognition of pathogen effectors and MAPK signaling. Mol. Plant-Microbe Interact. 32: 1496-1507.

 

Majhi, B. B., S. Sreeramulu and G. Sessa (2019). BRASSINOSTEROID-SIGNALING KINASE5 associates with immune receptors and is required for immune responses. Plant Physiol. 180: 1166-1184.

 

Dubrow, Z., S. Sunitha, J-G Kim, C. D. Aakre, A. Madhusoodana, G. Sobol, Girija, D. Teper, Y. C. Chen, N. Ozbaki-Yagan, H. Vance, G. Sessa and M. B. Mudgett (2018). Tomato 14-3-3 proteins are required for Xv3 disease resistance and interact with a subset of Xanthomonas euvesicatoria effectors. Mol. Plant-Microbe Interact. 31: 1301-1311.

 

Popov, G., B. B. Majhi and G. Sessa (2018). Effector gene xopAE of Xanthomonas euvesicatoria 85-10 is part of an operon and encodes an E3 ubiquitin ligase. J. Bacteriol. 200: e00104-18.

 

Teper, D., A. M. Girija, E. Bosis, G. Popov, A. Savidor and G. Sessa (2018). The Xanthomonas euvesicatoria type III effector XopAU is an active protein kinase that manipulates plant MAP kinase signaling. PLoS Pathogens 14: e1006880.

 

Chalupowicz, L., G. Nissan, M. T. Brandl, M. McClelland, G. Sessa, G. Popov, I. Barash, and S. Manulis-Sasson (2018). Assessing the ability of Salmonella enterica to translocate type III effectors into plant cells. Mol. Plant-Microbe Interact. 31: 233-239.

 

Nissan, G., M. Gershovits, M. Morozov, L. Chalupowicz, G. Sessa, S. Manulis-Sasson, I. Barash, and T. Pupko (2018). Revealing the inventory of type III effectors in gall-forming pathovars of Pantoea agglomerans by using draft genome sequences and a machine-learning approach. Mol. Plant Pathol. 19: 381-392.

 

Chalupowicz, L., I. Barash, M. Reuven, O. Dror, G. Sharabani, K-H. Gartemann, R. Eichenlaub, G. Sessa, and S. Manulis-Sasson (2017). Differential contribution of Clavibacter michiganensis subsp. michiganensis virulence factors to systemic and local infection in tomato. Mol. Plant Pathol. 18: 336-346.

 

Popov, G., M. Fraiture, F. Brunner, and G. Sessa (2016). Multiple Xanthomonas euvesicatoria type III effectors inhibit flg22-triggered immunity. Mol. Plant-Microbe Interact. 29: 651-660.

 

Teper, D., D. Burstein, D. Salomon, M. Gershovitz, T. Pupko, and G. Sessa (2016). Identification of novel Xanthomonas euvesicatoria type III effector proteins by a machine-learning approach. Mol. Plant Pathol. 17: 398-411.

 

Popa, C., N. S. Coll, M. Valls, and G. Sessa (2016). Yeast as a heterologous model system to uncover type III effector function. PLoS Pathogens 12: e1005360.

 

Teper, D., S. Sunitha, G. B. Martin, and G. Sessa (2015). Five Xanthomonas type III effectors suppress cell death induced by components of immunity-associated MAP kinase cascades. Plant Signal. Behav. 10: e1064573.

 

Savidor, A., D. Teper, K-H. Gartemann, R. Eichenlaub, L. Chalupowicz, S. Manulis-Sasson, I. Barash, G. Sessa (2014). Clavibacter michiganensis subsp. michiganensis Vatr1 and Vatr2 transcriptional regulators are required for virulence in tomato. Mol. Plant-Microbe Interact. 27: 1035-1037.

 

Zheng, X., H. McLellan, M. Fraiture, X. Liu, P. C. Boevink, E. M. Gilroy, Y. Chen, K. Kandel, G. Sessa, P. R. J. Birch, F. Brunner (2014). Functionally redundant RXLR effectors from Phytophthora infestans suppress early flg22-triggered immunity, above or immediately below the level of MAP kinase activation. PLoS Pathogens 10: e1004057.

 

Savidor, A., D. Teper, K-H. Gartemann, R. Eichenlaub, L. Chalupowicz, S. Manulis-Sasson, I. Barash, G. Sessa (2014). Clavibacter michiganensis subsp. michiganensis Vatr1 and Vatr2 transcriptional regulators are required for virulence in tomato. Mol. Plant-Microbe Interact. 27: 1035-1047.

 

Teper, D., D. Salomon, S. Sunitha, J-G. Kim, M. B. Mudgett and G. Sessa (2014). Xanthomonas euvesicatoria type III effector XopQ interacts with tomato and pepper 14-3-3 isoforms to suppress effector-triggered immunity. Plant J. 77: 297-309.

 

Molecular Plant Immunity, pp. 277 (2013). Editor: G. Sessa. Wiley-Blackwell, a John Wiley & Sons Inc. Publications.

 

Panijel, M., L. Chalupowicz, G. Sessa, S. Manulis-Sasson, I. Barash (2013). Global regulatory networks control the Hrp regulon of the gall-forming bacterium Pantoea agglomerans pv. gypsophilae. Mol. Plant-Microbe Interact. 26: 1031-1043.

 

Chalupowicz, L., D. Weinthal, V. Gaba, G. Sessa, I. Barash, S. Manulis-Sasson (2013). Polar auxin transport is essential for gall formation by Pantoea agglomerans on gypsophila. Mol. Plant Pathol. 14: 185-190.

 

Gruetter, C., S. Sreeramulu, G. Sessa, D. Rauh (2013). Structural characterization of the RLCK family member BSK8: a pseudokinase with an unprecedented architecture. J. Mol. Biol. 425: 4455-4467.

 

Sreeramulu, S., Y. Mostizky, S. Sunitha, H. Nahum, E. Shani, D. Salomon, L. Ben Hayun, C. Gruetter, D. Rauh, N. Ori, and G. Sessa (2013). BSKs are partially redundant positive regulators of brassinosteroid signaling in Arabidopsis. Plant J. 74: 905-919.

 

Salomon, D., E. Bosis, D. Dar, I. Nachman, G. Sessa (2012). Expression of Pseudomonas syringae type III effectors in yeast under stress conditions reveals that HopX1 attenuates activation of the high osmolarity glycerol MAP kinase pathway. Microbiology 158: 2859-2869.

 

Nissan, G., S. Manulis-Sasson, L. Chalupowicz, D. Teper, A. Yeheskel, M. Pasmanik-Chor, G. Sessa, I. Barash (2012). The type III Effector HsvG of the gall-forming Pantoea agglomerans mediates expression of the host gene hsvGT. Mol. Plant-Microbe Interact. 25: 231-240.

 

Chalupowicz, L., E.M. Zellermann, M. Fluegel, O. Dror, R. Eichenlaub, K-H. Gartemann, A. Savidor, G. Sessa, N. Iraki, I. Barash, S. Manulis-Sasson (2012). Colonization and movement of GFP-labeled Clavibacter michiganensis subsp. michiganensis during tomato infection. Phytopathology 102: 23-31.

 

Savidor, A., D. Teper, K-H. Gartemann, R. Eichenlaub, L. Chalupowicz, S. Manulis-Sasson, I. Barash, H. Tews, K. Mayer, R. Giannone, R. Hettich, and G. Sessa (2012). The Clavibacter michiganensis subsp. michiganensis–tomato interactome reveals perception of pathogen by host and suggests mechanisms of infection. J. Proteome Res. 11: 736-750.

 

Bosis, E., Salomon, D. and G. Sessa (2011). A simple yeast-based strategy to identify host cellular processes targeted by bacterial effector proteins. PLoS ONE 6: e27698.

 

Melech-Bonfil S. and G. Sessa (2011). The SlMKK2 and SlMPK2 genes play a role in tomato disease resistance to Xanthomonas campestris pv. vesicatoria. Plant Signal. Behav. 6: 154-156.

 

Salomon, D., D. Dar, S. Sreeramulu and G. Sessa (2011). Expression of Xanthomonas campestris pv. vesicatoria type III effectors in yeast affects cell growth and viability. Mol. Plant-Microbe Interact. 24: 305-314.

 

Sharfman, M., M. Bar, M. Erlich, S. Schuster, S. Melech-Bonfil, R. Ezer, G. Sessa, A. Avni (2011). Endosomal signaling of the tomato leucine rich repeat receptor-like protein LeEix2. Plant J. 68: 413-423.

 

Balaji, V., G. Sessa, C. D. Smart (2011). Silencing of host basal defense response-related gene expression increases susceptibility of Nicotiana benthamiana to Clavibacter michiganensis subsp. michiganensis. Phytopathology 101: 349-357.

 

Weinthal,  D. M., I. Barash, T. Tzfira, V. Gaba, D. Teper, G. Sessa, S. Manulis-Sasson (2011). Characterization of nuclear localization signals in the type III effectors HsvG and HsvB of the gall-forming bacterium Pantoea agglomerans. Microbiology 157: 1500-1508.

 

Melech-Bonfil S. and G. Sessa. Tomato MAPKKKε is a positive regulator of cell-death signaling networks associated with plant immunity (2010). Plant J. 64: 379-391.

 

Salomon, D. and G. Sessa (2010). Identification of growth inhibition phenotypes induced by expression of bacterial type III effectors in yeast. J. Visual. Exp. http://www.jove.com/index/details.stp?id=1865, doi: 10.3791/1865.

 

Chalupowicz, L., M. Cohen-Kandli, O. Dror, R. Eichenlaub, K-H. Gartemann, G. Sessa, I. Barash, S. Manulis-Sasson (2010). Sequential expression of bacterial virulence and plant defense genes during infection of tomato with Clavibacter michiganensis subsp. michiganensis. Phytopathology 100: 252-261.

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