Prof. Judith Berman

  • Biotechnology
מקרוביולוגיה מולקולרית סגל אקדמי בכיר
Prof. Judith Berman
Phone: 03-6407633
Another phone: 03-6407536
Fax: 03-6407499
Office: Britannia-Porter, 418

CV

Education:

1979 B.Sc. Cornell University, Plant Pathology
1985 Ph.D. Weizmann Institute of Science, Biochemistry
1984 Post doctoral fellow, Cornell University, Genetics

 

Academic Appointments:

2012-present Full Professor, Department of Molecular Biology & Biotechnology, Tel Aviv University
2000-2012 Full Professor, Genetics, Cell Biology & Development, University of Minnesota, Minneapolis MN USA
2000-2012 Adjunct Full Professor, Microbiology, University of Minnesota
2000-2002 Associate Department Head, Genetics, Cell Biology and Development, University of Minnesota
1999-2000 Associate Professor, Genetics, Cell Biology & Development, Univ. of Minnesota
1999-2000 Adjunct Associate Professor, Microbiology, University of Minnesota
1993-1999 Associate Professor, Plant Biology, University of Minnesota, Minneapolis
1986-1993 Assistant Professor, Plant Biology, University of Minnesota, Minneapolis

 

Other Appointments and Awards:

2011 Jacob and Lena Joels Memorial Foundation Visiting Professor, Hebrew University of Jerusalem, Israel
2010 Weston Visiting Professor, Dept. of Computer Science and Applied Mathematics, Weizmann Institute of Science, Israel
2008 Distinguished McKnight University Professor
2007 Fellow of the American Academy for the Advancement of Science
2007 Fellow of the American Academy of Microbiology
2004 Visiting Scientist, Molecular Genetics, Weizmann Inst. of Science, Israel
1997 Burroughs Wellcome Senior Scholar in Molecular Pathogenic Mycology
1996 Established Investigator of the NIH Child Health Research Center
1994 National Science Foundation: Career Advancement Award
1994 Bantrell-Weizmann: Postdoctoral Fellowship

 

Research Interests

We are interested in how genomes evolve and change in response to the stresses that assault a cell.  We study Candida albicans, the most prevalent fungal commensal and pathogen of humans.  We are interested in how it responds to antifungal drugs and how it manages to evolve drug resistance very rapidly.  Our work spans studies of chromosome structure, chromosome stability, integrity and inheritance as well as regulation of the life cycle and the cell cycle.  This touches on topics including morphogenesis, ploidy, recombination and repair of damage.  In addition, we develop tools that facilitate work in this important fungal pathogen.

 

Featured Link

Recent Publications

For a full list, please see her website

 

2015

Gerstein, A., Fu, S., Mukaremera, L., Li, Z., Ormerod, K.L., Fraser, J.A.,  Berman, J., Nielsen, K.. 2015 Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation mBio. In press.

 

McCoy, K.M., Tubman, E.S., Claas, A., Tank,D., Applen Clancy, S., O’Toole, E.T., J. Berman, and D.J. Odde. 2015 Physical limits on kinesin-5 mediated chromosome congression in the smallest mitotic spindles,  Mol. Biol Cell. In press.

 

Gerstein, A., and J. Berman. 2015 Shift and adapt: the costs and benefits of karyotype variations. Curr. Opin. Microbiol. 2015 doi: 10.1016/j.mib.2015.06.010

 

Chen, G, Mulla, W.A., Kucharavy, A, Tsai, H-J., Rubinstein, B., Conkright, J., Scott McCroskey, S., Bradford, W.D., Weems, L. , Haug, J.S., Seidel, C.W., Berman, J. and R. Li. 2014. Targeting the Adaptability of Heterogeneous Aneuploids CELL, 160, 771–784, doi:10.1016/j.cell.2015.01.026.

 

Sullivan, D.J, Berman, J. Myers, L.C and G.P. Moran. 2015. Telomeric ORFS in Candida albicans: does Mediator tail wag the yeast? PLoS Pathogens, 11(2): e1004614. doi:10.1371/journal.ppat.1004614.

 

Ford, C.B., Funt, J.M., Abbey, D.A., Issi, L., Guiducci, C., Martinez, D.A,, Delorey, T, Li, B.U., White, T.C., Cuomo, C., Prusty-Rao, R., Berman,J., A. Thompson, D., and A. Regev. 2014. The mutational landscape of gradual acquisition of drug resistance in clinical samples of Candida albicans eLife,  2015;4:e00662. DOI: 10.7554/eLife.00662.

 

Kashem, S.W., Igyarto, B.Z., Gerami-Nejad, ., Kumamoto, Y., Jarrett, E., Drummond, R.A., Zurawski, S.M., Zurawski, G., Berman, J., Iwasaki, A., Brown, G.D., and D.H. Kaplan. 2015. Candida albicans morphology and DC subsets determine T-helper differentiation. Immunity, 42: 356-66 10.1016/j.immuni.2015.01.008

 

Anderson, M.Z., Wigen, L.J., Burrack, L.S. and J. Berman 2015 Real-time evolution of a subtelomeric gene family, Genetics, 200: 907–919 doi: 10.1534/genetics.115.177451

 

Hickman, M.A., Paulson, C., Dudley, A. and J. Berman 2015 Parasexual ploidy reduction drives population heterogeneity through random and transient aneuploidy in C. albicans GENETICS Vol. 200, 781–794 doi: 10.1534/genetics.115.178020.

 

2014

Matthew P. Hirakawa, Diego A Martinez, Sharadha Sakthikumar, Matthew Anderson, Aaron Berlin, Sharvari Gujja, Qiandong Zeng, Ethan Zisson, Joshua M Wang, Joshua M Greenberg, Judith Berman, Richard J Bennett, and Christina A Cuomo. Genetic and phenotypic intra-species variation. Candida Albicans. 2014 Dec 11. doi:10.1101/gr. 174623.114 

 

Bennett, R.J., Forche, A., and Berman, J. Rapid Mechanisms for Generating Genome Diversity:Whole Ploidy Shifts, Aneuploidy, and Loss of Heterozygosity. 2014 Jul 31. pii: a019604. doi: 10.1101/cshperspect.a019604. 

 

Harrison, B.D., Hashemi, J., Bibi, M., Pulver, R., Bavli, D., Nahmias, Y, Wellington, M., Sapiro, G., and J. Berman, A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole. PLoS Biology, 12(3):e1001815.

 

Anderson, M.Z., Gerstein, A.C., Wigen, L.J. Baller, J.A.,and Berman, J. 2014. Silencing is noisy: Population and cell level noise in telomere-adjacent genes is dependent on telomere position and Sir2.  PLoS Genetics  10.1371/journal.pgen.1004436 

 

Hickman, M.A, Zeng, G, Forche, A., Hirakawa,M.P., Abbey,D., Harrison, B.D., Wang, Y-M. Su, C-h., Bennett, R.J., Wang, Y and J. Berman, 2012. The “obligate diploid” Candida albicans forms mating-competent haploids. Nature, in press. 

 

Burrack LS, Applen clancey SE, Chacón JM, Gardner MK, Berman J. Monopolin recruits condensin to organize centromere DNA and repetitive DNA sequences. Mol Biol Cell. 2013; 

 

Gerami-Nejad, M., Zacchi, L.F., McClellan, M., Matter, K. and J. Berman,Shuttle vectors for facile gap repair cloning and integration into a neutral locus in Candida albicans Microbiology (2013), 159, 565–579. 

 

Hickman, M.A, Zeng, G, Forche, A., Hirakawa,M.P., Abbey,D., Harrison, B.D., Wang, Y-M. Su, C-h., Bennett, R.J., Wang, Y and J Berman,The ‘obligate diploid’ Candida albicans forms mating-competent haploids. Nature, 494:55-59 

 

Berman, J. 2012. Quick Guide: Candida albicans. Current Biology. 22(16):R620-22.

 

Anderson, M.Z, Baller, J.A., Dulmage, K., Wigen, L. and Berman, J. 2012. The three clades of the telomere-associated 1 TLO gene family of Candida albicans have different splicing, localization and expression features. Eukaryotic Cell, 11(10): 1268-1275.

 

Gerami-Nejad, Forche, A., McClellan, M., and Berman, J. 2012. Analysis of protein function in clinical Candida albicans isolates. Yeast. 29(8):303-309. PMID: 22777821; NIHMSID#390377.

 

Burrack, L.S. and Berman, J. 2012. Flexibility of centromere and kinetochore structures. Trends in Genetics. 28:204-212.

 

 

Burrack, L.S. and Berman, J. 2012. Neocentromeres and epigenetically inherited features of centromeres. Chromosome Res. DOI 10.1007/s10577-012-9296-x.

 

Berman, J and L. Hadany. 2012. Does stress induce (para)sex? Implications for Candida albicans evolution. Trends in Genetics, in press.

 

Forche, A., Abbey, D., Pisithkul, T., Weinzierl, M.A., Ringstrom, T., Bruck, D., Petersen, K., and J Berman. 2011. MBio® 2(4). e00129-11. 

 

Abbey, D., Hickman, M., Gresham, D. and J. Berman. 2011. High-resolution SNP/CGH microarrays reveal the accumulation of loss of heterozygosity in commonly used Candida albicans strains. G3:Genes, Genomes, Genomics 1:523.

 

Huang M, McClellan M, Berman J, Kao KC. Evolutionary Dynamics of Candida albicans during In Vitro Evolution. Eukaryot Cell. 2011 10:1413-21.

 

Burrack, L.S., Applen, S. and J. Berman. 2011. The requirement for the Dam1 complex is dependent upon the number of kinetochore proteins and microtubules. Current Biology, 21:889-896. F1000 “Recommended”

 

Selmecki, A.M., Forche, A., and J. Berman. 2010. Genomic Plasticity of the Human Fungal Pathogen Candida albicans. Eukaryotic Cell, 9(7):991-1008 (doi:10.1128/EC.00060-10). (3.871; 33/95)

 

Koren, A., Tsai, H-J., Tirosh, I., Burrack, L., Barkai, N. and J. Berman.2010. Epigenetic inheritance of centromere location is associated with early DNA replication. PLoS Genetics, PLoS Genet 6(8): e1001068. doi:10.1371/journal.pgen.1001068. (9.532; 10/146). F1000 “Must Read”

 

Joglekar, A.P., Bouck, D., Finley, K., Liu, X., Wan, Y., Berman, J., He, X., Salmon, E.D. and K.S. Bloom. 2008. Molecular architecture of kinetochore-microtubule attachment sites is conserved between point and regional centromeres. J. Cell Biol. 121:466-76. (35 citations; 9.575; 15/162) F1000 ‘Must Read

 

Ketel, C., Wang, H.S.W., McClellan, M., Selmecki, A., Gerami-Nejad, M., Bouchonville, K. and J. Berman. 2009. Neocentromeres form efficiently at multiple possible loci in Candida albicans. PLoS Genetics, 5 (3): e1000400. (14 citations; 9.532; 10/146) F1000 “Recommended’.

 

Butler, G., et al. 2009. Evolution of pathogenicity and sexual reproduction revealed by comparing eight Candida genomes. Nature 459: 657-662. (51 citations; 34.48; 1/50)

 

Gerami-Nejad, M., Dulmage, K., and J. Berman. 2009. Additional cassettes for epitope and fluorescent fusion proteins in Candida albicans. Yeast, PMID: 19504625. (3 citations; 1.805; 199/283)

 

Forche, A., Magee, P., Selmecki, A. M., Berman, J., and G. May. 2009. Evolution in Candida albicans populations during single passage through a mouse host. Genetics, doi:10.1534/genetics.109.103325. (6 citations, 3.889; 38/146)

 

Forche, A., Steinbach, M., and J. Berman. 2009. Efficient and rapid identification of Candida albicans allelic status using SNP-RFLP. FEMS Yeast, 9(7):1061-69. (3 citation; 1.805; 199/283)

 

Bouchonville, K., Forche, A., Tang, K.E.S., Selmecki, A.M. and J. Berman. 2009. Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans. Eukaryotic Cell, 8(10):1554-66. PMID: 19700634. (6 citations, 3.871; 33/95)

 

Selmecki, A., K. Dulmage, L. Cowen, J.B. Anderson and J. Berman. 2009. Aneuploidy provides increased fitness during the evolution of antifungal drug resistance. PLOS Genetics, 5(10): e1000705.doi:10.1371/journal.pgen.1000705. PMID: 19876373 (2 citations; 9.532; 10/146), F1000 “Recommended”.

 

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