The CRCF Bioinformatics Unit

Our end-to-end bioinformatics services guide projects from raw sequencing data to biologically meaningful conclusions through tailored computational workflows.

We support a broad range of bioinformatics applications with a focus on genomics and high-throughput sequencing. Our workflows provide comprehensive data processing for:

Genomics & High-Throughput Analysis

· Bulk RNA-Seq

· DNA-seq

· Metagenomics

· ChIP-seq/ATAC-Seq/Cut&Tag

· Proteomics

· and more...

Advanced Modeling & Functional Interpretation

We extend beyond standard data processing to provide advanced statistical and computational modeling. We specialize in integrative functional interpretation using enrichment, pathway, and multi-omics approaches to uncover deep biological meaning.

Publication-Ready Data & Support

We partner closely with investigators to ensure all data analysis is fully rigorous and reproducible. Our goal is to help you translate complex biological data into clear, journal-vetted results.

View Our Collaborative Publications:

1. Pascal C*, Zonszain J*, Hameiri O, Gargi-Levi C, Lev-Maor G, Tammer L, Levy T, Tarabeih A, Roy VR, Ben-Salmon S, Elbaz L, Eid M, Hakim T, Abu Rabe’a S, Shalev N, Jordan A, Meshorer E, Ast G. Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation. Mol. Cell. 2023 Nov 2. *These authors contributed equally to this work.

2. Elkoshi N*, Parikh S*, Malcov-Brog H, Parikh R, Manich P, Netti F, Maliah A, Elkoshi H, Haj M, Rippin I, Frand J, Perluk T, Haiat-Factor R, Golan T, Regev-Rudzki N, Kiper E, Brenner R, Gonen P, Dror I, Levi H, Hameiri O, Cohen-Gulkar M, Eldar-Finkelman H, Ast G, Nizri E, Ziv Y, Elkon R, Khaled M,

Ebenstein Y, Shiloh Y, Levy C. ATM signaling delays skin pigmentation upon UV exposure by mediating MITF function toward DNA repair mode. J. Invest. Dermatol. 2023 May 25. *These authors contributed equally to this work.

3. Tammer L*, Hameiri O*, Keydar I*, Roy VR, Ashkenazy-Titelman A, Custódio N, Sason I, Shayevitch R, Rodríguez Vaello V, Rino J, Lev Maor G, Leader Y, Khair D, Lieberman Erez, Elkon R, Irimia M, Sharan R, Shav-Tal Y, Carmo-Fonseca M, Ast G. Gene architecture directs splicing outcome in separate nuclear spatial regions. Mol. Cell. 2022 Mar 3. *These authors contributed equally to this work.

4. Leader Y, Lev Maor G, Sorek M, Shayevitch R, Hussein M, Hameiri O, Tammer L, Zonszain J, Keydar I, Hollander D, Meshorer E, Ast G. The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis. Nat. Commun. 2021 Jul 27;12:4545.

Project Reports & Visualizations

Each project concludes with a structured, method-rich report and clear interpretation of findings. We deliver high-quality, publication-ready visualizations and provide professional figure refinement using Adobe Illustrator to ensure clarity and journal-ready presentation standards.