Prof. Frenkel Dan

מחלקה לנוירוביולוגיה סגל אקדמי בכיר
Prof. Frenkel Dan
Phone: 03-6409484
Fax: 03-6409028
Office: Sherman - Life Sciences, 424

Research Interests

Research area: Neuroimmunology, Neurodegeneration.

 

Current Research Topics:  The role of glia cells during central nervous system inflammation using models of stroke, Alzheimer's disease, Parkinson’s disease and multiple sclerosis.

 

 

Methods & Techniques: Neurobiology,Immunology, Cell biology, Molecular biology, Histology.

 

The  research in the laboratory focus  on glial-neuronal cell interactions to clarify their role in neurological diseases, both in culture and in animal models of Parkinson’s Disease, and Alzheimer’. The laboratory combines approaches such as molecular biology, immunological approaches, histological approach and behavioral approach to shed light on the genes and proteins involved in glial cell function, in particular microglia and astrocyte in neurodegenerative diseases. The laboratory developed novel approaches to isolate adult glia from mice and to investigate their genetic and proteins profile that relate to pathological condition. Research focus on the link between inflammation to neurodegenerative diseases and the laboratory develop and investigate new therapeutic approach to treat AD and has several approved patents.

 

Recent Publications

Levy H, Assaf Y, Frenkel D. Characterization of brain lesions in a mouse model of progressive multiple sclerosis. Exp Neurol. 2010 226(1):148-58.

 

Farfara D., Trudler D., Amzaleg-Segev  N., Galron R., Stein R., Frenkel D. Gamma-secretase component presenilin mediates microglia beta amyloid clearance. Ann Neurology, 2011, 69(1):170-80. doi: 10.1002/ana.22191.

 

Weiss  R. Lifshitz  V, Frenkel  D. TGF-β1 affects endothelial cell interaction with macrophage and Th1 T-cells leading to the development of cerebrovascular amyloidosis”Brain Behav Immun.2011 Jul;25(5):1017-24

  

Lifshitz V., Benromano T., Kfir E.,  Blumenfeld-Katzir T. , Tempel-Brami  C. Assaf   Y., Xia  W., Wyss-Coray  T., Weiner  HL, and Frenkel  D.. “Immunotherapy of cereberovascular amloidosis in a transgenic mouse model” , Neurobiology of aging, 2012  33(2):432.e1-432.e13

 

Levy-Barazany H. , Frenkel D. “Expression of Scavenger receptor A on antigen presenting cells is important for CD4+T-cells proliferation in EAE mouse model.” Journal of Neuroinflammation 2012, 9:120doi: 10.1186/1742-2094-9-120.

 

Segev-Amzaleg N, Trudler D, Frenkel D.Preconditioning to mild oxidative stress mediates astroglialneuroprotection in an IL-10-dependent manner. Brain Behav Immun. 2013 30: 176-185

 

Trudler D, Weinreb O, Mandel SA, Youdim MB, Frenkel D. DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline. J Neurochem. 2014;129(3):434-47.

 

Iram T., Byrne MH, Coleman UA, Kingery ND, Ramirez-Ortiz Z, Means TK, Frenkel D, El Khoury J.MEGF10 IS A RECEPTOR FOR C1Q AND MEDIATES CLEARANCE OF APOPTOTIC CELLS BY ASTROCYTES. Journal of Neuroscience (2016) 11;36(19):5185-92.

 

Iram T, Trudler D, Kain D, Kanner S, Galron R, Vassar R, Barzilai A, Blinder P, Fishelson Z, Frenkel D. Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection. Neurobiol Dis. 2016;96:84-94.

 

Nash Y, Schmukler E, Trudler D, Pinkas-Kramarski R, Frenkel D. DJ-1 deficiency impairs autophagy and reduces alpha-synuclein phagocytosis by microglia. J Neurochem. 2017 :143(5):584-594.

 

Trudler D, Levy-Barazany H, Nash Y, Samuel L, Sharon R, Frenkel D. Alpha synuclein deficiency increases CD4+ T-cells pro-inflammatory profile in a Nurr1-dependent manner. J Neurochem. 2020;152(1):61–71. doi:10.1111/jnc.14871.

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