Prof. Pablo Blinder

Department of Neurobiology
Faculty of Life Sciences
מחלקה לנוירוביולוגיה סגל אקדמי בכיר
Prof. Pablo Blinder
Phone: 03-6409640
Another phone: 03-6405621
Fax: 03-6405621
Office: Sherman - Life Sciences, 419

Research Interests

Research topic: Understanding the physiology and structure of the neurovascular interface under normal and pathological conditions.


Research methods: In vivo, awake multi-photon imaging. High-content histology and data mining. Multi-modal hemodynamic imaging. Multi-electrode array recording.


Main projects in the lab include:

  • Quantitative description of the structure-function relationship behind the neurovascular interface
  • Degeneration of the neurovascular interface and its role in neurodegenerative diseases
  • Population coding of integrative sensory inputs


Recent Publications

P Blinder*, P. S. Tsai*, J. K. Kaufhold, P. M. Knudsen, H. Suhl and D. Kleinfeld. The cortical angiome: A 3-D interconnected vascular network with noncolumnar patterns of blood flow.  Nature Neuroscience (2013) 16:889-897. *Equal contribution [PDF] A 2-star F1000Prime selection.    The Research Brief “Mouse brain circulatory system knows no bound?” appeared in the Alzheimer Research Forum.    Articles based on the UCSD press release “3-D map of blood vessels in cerebral cortex holds surprises” appeared in Africa-News, Association Alzheimer-Riese (Italy), Bio-Medicine, EurekAlert, Health Medicine Network, Journaux-Francais, MedicalPress (Spain), MyScience, News-Medical (France; Germany; Italy; Korea Poland; Russia; Spain), ScienceDaily, and ZeeNews. The article “In Natural Networks, Strength in Loops” by Emily Singer appeared in the Quanta Magazine.


A. Y. Shih, P. Blinder, P. S. Tsai, B. Friedman, G. Stanley, P. D. Lyden and D. Kleinfeld. The smallest stroke : occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nature Neuroscience (2013), 16(1):55:63. [PDF]


J. P. Kaufhold, P. S. Tsai, P. Blinder and D Kleinfeld. Vectorization of optically sectioned brain microvasculature: learning aids completion of vascular graphs by connecting gaps and deleting open- ended segments. Medical image analysis (2012), 16(6):124158. [PDF]


D. Kleinfeld, A. Bharioke, P. Blinder, D. D. Bock, K. L. Briggman, D. B. Chklovskii, W. Denk, M. Helmstaedter, J. P. Kaufhold, W.-C. a. Lee, H. S. Meyer, K. D. Micheva, M. Oberlaender, S. Prohaska, R. C. Reid, S. J. Smith, S. Takemura, P. S. Tsai, and B. Sakmann. Large- Scale Automated Histology in the Pursuit of Connectomes. Journal of Neuroscience (2011), 31(45):1612516138 [PDF]


D. Kleinfeld, P. Blinder, P. J. Drew, J. D. Driscoll, A. Muller, P. S. Tsai and A. Y. Shih. A guide to delineate the logic of neurovascular signaling in the brain. Frontiers in Neuroenergetics (2011): Special Issue on Neurovascular Imaging 3 (1). [PDF]


P. J. Drew, A. Y. Shih, P. S. Tsai, P. Knutsen, D. Davalos, P. Blinder, K. Akassoglou and D. Kleinfeld. Large-scale chronic imaging and optical manipulation of cortical cells through a polished and reinforced thinned-skull. Nature Methods (2010), 7(12):981984. [PDF]


P. Blinder*, A. Y. Shih*, C. A. Rafie and D. Kleinfeld. Topological basis for the robust distribution of blood to rodent neocortex. PNAS (2010). Volume 107, Issue 28, 12670-12675. *Equal contribution. 10.1073/pnas.1007239107 [PDF]


Ehud Cohen, Johan F. Paulsson, Pablo Blinder, Tal Burstyn-Cohen, Deguo Du, Gabriela Es- tepa, Anthony Adame, Hang M. Pham, Martin Holzenberger, Jeffery W. Kelly, Eliezer Masliah and Andrew Dillin. Reduced IGF-1 Signaling Delays Age-associated Proteotoxicity in Mice Cell (2009) Volume 139, Issue 6, 1157-1169, 11. doi:10.1016/j.cell.2009.11.014 [PDF]


Philbert. S. Tsai, John. P. Kaufhold, Pablo. Blinder, Beth. Friedman, Patrick. J. Drew, Harvey. J. Karten, Patrick. D. Lyden and David. Kleinfeld. Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci. 2009 Nov 18;29(46):14553-70. doi:10.1523/JNEUROSCI.3287-09.2009 [PDF]


Patrick J. Drew, Pablo Blinder, Gert Cauwenberghs, Andy Y. Shih and David Kleinfeld. Rapid determination of particle velocity from space-time images using the Radon transform. Journal of Computational Neuroscience 2009. doi:10.1007/s10827-009-0159-1 [PDF]


Tsai PS, Blinder P, Migliori BJ, Neev J, Jin Y, Squier JA, Kleinfeld D. Plasma-mediated ab- lation: an optical tool for sub micrometer surgery on neuronal and vascular systems. Cur- rent Opinion in Biotechnology (2009) Vol 20, Issue 1, 90-97. PubMed PMID: 19269159. doi:10.1016/j.copbio.2009.02.003 [PDF]


Blinder P, Cove J, Foox M, Baranes D. Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity. PLoS ONE. 2008;3(11):e3782. Epub 2008 Nov 21. PubMed PMID: 19023423; PubMed Central PMCID: PMC2582457. doi:10.1371/journal.pone.0003782 [PDF]


Cove J, Blinder P, Baranes D. Contacts among non-sister dendritic branches at bifurcations shape neighboring dendrites and pattern their synaptic inputs. Brain Res. 2009 Jan 28;1251:30- [PDF]


Peretz H, Blinder P, Baranes D, Vago R. Aragonite crystalline matrix as an instructive microen- vironment for neural development. J Tissue Eng Regen Med. 2008 Dec;2(8):463-71. PubMed PMID: 18924122. doi:10.1002/term.118 [PDF]


Baranes D, Cove J, Blinder P, Shany B, Peretz H, Vago R. Interconnected network of ganglion- like neural cell spheres formed on hydrozoan skeleton. Tissue Eng. 2007 Mar;13(3):473-82. PubMed PMID: 17518598. doi:10.1089/ten.2006.0052 [PDF]


Shany B, Peretz H, Blinder P, Lichtenfeld Y, Jeger R, Vago R, Baranes D. Aragonite crys- talline biomatrices support astrocytic tissue formation in vitro and in vivo. Tissue Eng. 2006 Jul;12(7):1763-73. PubMed PMID: 16889507. doi:10.1089/ten.2006.12.1763 [PDF]


Sorkin R, Gabay T, Blinder P, Baranes D, Ben-Jacob E, Hanein Y. Compact self-wiring in cultured neural networks. J Neural Eng. 2006 Jun;3(2):95-101. Epub 2006 Apr 11. PubMed PMID: 16705265. doi: 10.1088/1741-2560/3/2/003 [PDF]


Cove J*, Blinder P*, Abi-Jaoude E*, Lafrenire-Roula M, Devroye L, Baranes D. Growth of neurites toward neurite- neurite contact sites increases synaptic clustering and secretion and is regulated by synaptic activity. Cereb Cortex.2006 Jan;16(1):83-92. Epub 2005 Apr 27. *Equal contribution. PubMed PMID: 15858165. doi:10.1093/cercor/bhi086 [PDF]


Blinder P, Baruchi I, Volman V, Levine H, Baranes D, Ben-Jacob E (2005) Functional Topology Classification of Biological Computing Networks. Natural Computing 4: 339 361. doi:10.1007/s11047-005-3667-6 [PDF]


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