Prof. Eran Bacharach

פקולטה למדעי החיים

Email: eranbac@post.tau.ac.il

Phone: 03-6407692

משרד:

בריטניה, 404

Biography

Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the Hebrew University and conducted his postdoctoral research at the laboratory of Prof. Stephen P. Goff , Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University.

Research Interests

My research interests are:

Molecular virology;
Replication of human and animal RNA viruses in general and of retroviruses and metapneumoviruses in particular;
Oncolytic viruses;
Gene transfer with retroviral vectors;
Analysis of virus-host interactions;
Innate immune response to viral infections.

Recent Publications

Selected works

E. Elis , M. Ehrlich, A. Prizan-Ravid, N. Laham-Karam, E. Bacharach. p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes. PLoS Pathogens 2012 Dec 8, e1003103.

D. Nachmias,E.H. Sklan, M. Ehrlich, and E. Bacharach. Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway. Retrovirology. 2012 Vol. 9, pp. 1-7.

Sabo Y, Ehrlich M, Bacharach E. The conserved YAGL motif in the human metapneumovirus is required for higher ordered cellular assemblies of the matrix protein and for virion production. J. Virol. 2011 Apr 27. 85, pp. 6594–6609. 2011.

A. Prizan-Ravid , E. Elis , N. Laham-Karam , S. Selig , M. Ehrlich, E. Bacharach. The Gag Cleavage Product, p12, is a Functional Constituent of the Murine Leukemia Virus Pre-Integration Complex. PLoS Pathogens. 2010 Nov 11;6(11):e1001183.

C. Banet-Noach, L. Simanov, N. Laham-Karam, S. Perk, E. Bacharach. Longitudinal survey of avian metapneumoviruses in poultry in Israel: Infiltration of field strains into vaccinated flocks. Avian Diseases. 2009 Jun Vol. 53, No. 2, pp. 184–189.

O. Penn, A. Stern, ND. Rubinstein, J. Dutheil, E. Bacharach, N. Galtier, T. Pupko. A novel evolutionary model of rate-shifts reveals specificity determinants in HIV-1 subtypes. PLoS Comput Biol. 2008 Nov; 4(11):e1000214.

Y. Sabo, N. Laham-Karam, E. Bacharach. Basal Budding and Replication of the Murine Leukemia Virus are Independent of the Gag L-Domains. J. Virol. 2008 Oct 82(19):9770-9775.

M. Levy, Y. Porat, E. Bacharach, D.E. Shalev, E. Gazit. Phenolsulfonphthalein, but not phenolphthalein, inhibits amyloid fibril formation: implications for the modulation of amyloid self-assembly. Biochemistry. 2008 Jun 3;47(22):5896-904.

N. Laham, E. Bacharach. Transduction of human immunodeficiency virus type 1 (HIV-1) vectors lacking the encapsidation and dimerization signals. J. Virol. Vol. 81(19), 2007 (pp. 10687-98).

I. Mayrose, A. Doron-Faigenboim, E. Bacharach, T. Pupko. Towards realistic codon models: among site variability and dependency of synonymous and nonsynonymous rates. Bioinformatics. Vol. 23, 2007 (pp. i319-i327).

A. Stern, A. Doron-Faigenboim, E. Erez, E. Martz, E. Bacharach, T. Pupko. Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach. Nucleic Acids Res. Vol. 35(Web Server issue), 2007 (pp. W506-11).

R. Efrony, Y. Loya, E. Bacharach, E. Rosenberg. Phage therapy of coral disease. Coral Reefs Vol. 26, 2007 (pp. 7–13).

Z. Cohen, E. Bacharach, S. Lavi. Mouse major satellite DNA is prone to eccDNA formation via DNA Ligase IV-dependent pathway. Oncogene. Vol. 25(33), 2006 (pp.4515-4524).

Y. Gruper, J. Bar, E. Bacharach, R. Ehrlich. The transferrin receptor interacts with the Hemochromatosis factor (HFE) and the Divalent Metal Transporter - 1 (DMT1) in trophoblast. J Cell Physiol. Vol. 204(3), 2005 (pp.901-912).

M. Mark-Danieli, N. Laham, M. Kenan-Eichler, A. Castiel, D. Melamed, M. Landau, N. M. Bouvier, M. J. Evans, E. Bacharach. Single point mutations in the zinc-finger motifs of HIV-1 nucleocapsid alter RNA-binding specificities of the Gag protein and enhance packaging and infectivity. J. Virol. Vol. 79(12), 2005 (pp.7756–7767).

A. Doron-Faigenboim, A. Stern, I. Mayrose, E. Bacharach, Tal Pupko. Selecton: A server for detecting evolutionary forces at a single amino-acid site. Bioinformatics. Vol. 21(9), 2005 (pp. 2101 –2103).

A. Zipin, M. Israeli-Amit, T. Meshel, O. Sagi-Assif, I. Yron, V. Lifshitz, E. Bacharach, N.I. Smorodinsky, A. Many, P.A. Czernilofsky, D.L. Morton, I.P. Witz. Tumor-microenvironment interactions: The fucose-generating FX enzyme controls adhesive properties of colorectal cancer cells. Cancer Res. Vol. 64(18), 2004 (pp. 6571-6578).

D. Melamed, M. Mark-Danieli, M. Kenan-Eichler, O. Kraus, A. Castiel, N. Laham, T. Pupko, F. Glaser, N. Ben-Tal, E. Bacharach. The conserved carboxy-terminus of the human immunodeficiency virus type 1 capsid domain of the Gag protein is important for virion assembly and release. J. Virol. Vol. 78(18), 2004 (pp.9675–9688).

I. Amit, L. Yakir, M. Katz, Y. Zwang, M.D. Marmor, A. Citri, K. Shtiegman, I. Alroy, S. Tuvia, Y. Reiss, E. Roubini, M. Cohen, R. Wides, E. Bacharach, U. Schubert, Y. Yarden. Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding. Genes Dev. Vol.18(14), 2004 (pp.1737-1752).

M. J. Evans, E. Bacharach, S.P. Goff. RNA sequences in the Moloney murine leukemia virus genome bound by the gag precursor protein in the yeast three-hybrid system. J. Virol. Vol. 78(14), 2004 (pp. 7677-7684).

J. Gonsky, E. Bacharach, S.P. Goff. Identification of Residues of the Moloney Murine Leukemia Virus Nucleocapsid Critical for Viral DNA Synthesis In Vivo. J Virol. Vol. 75(6), 2001 (pp. 2616–2626).

E. Bacharach, J. Gonsky, K. Alin, M. Orlova, S.P. Goff. The Carboxyterminus of Nucleolin Interacts with the Nucleocapsid Domain of Retroviral Gag Proteins and Inhibits Virion Assembly. J Virol. Vol. 74(23), 2000 (pp. 11027-11039).

B. Yuan, S. Campbell, E. Bacharach, A. Rein, S.P. Goff. Infectivity of Moloney murine leukemia virus defective in late assembly events can be restored by late assembly domains of other retroviruses. J Virol. Vol. 74(16), 2000 (pp. 7250-7260).

E. Bacharach, J. Gonsky, D. Lim, S.P. Goff. Deletion of a short, untranslated region adjacent to the polypurine tract in moloney murine leukemia virus leads to formation of aberrant 5' plus-strand DNA ends In vivo. J Virol. Vol. 74, 2000 (pp. 4755-4764).

E. Bacharach, S.P. Goff. Binding of the human immunodeficiency virus type 1 Gag protein to the viral RNA encapsidation signal in the yeast three-hybrid system. J Virol. Vol. 72, 1998 (pp. 6944-6949).

Bacharach, A. Itin, E Keshet. Apposition-dependent induction of plasminogen activator inhibitor type 1 expression: A mechanism for balancing pericellular proteolysis during angiogenesis. Blood Vol. 92, 1998 (pp. 939-945).

E. Bacharach, A. Itin, E Keshet. In Vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis. Proc. Natl. Acad. Sci. USA Vol. 89, 1992 (pp. 1068-10690).