Prof. Adit Ben-Baruch

מח חקר התא ואימונולוגיה סגל אקדמי בכיר
Prof. Adit Ben-Baruch
Phone: 03-6407933
Another phone: 03-6405491
Fax: 03-6422046
Office: Britannia-Porter, 307

Research Interests

The aim of our studies is to provide better and personalized therapeutic modalities in breast cancer. Our approach is based on understanding the way the inflammatory/immune microenvironment affects pro-malignancy functions in breast tumor cells and its impact on tumor-stroma interactions.  So far, our studies have provided important information on the roles of inflammation and immunity in malignancy in general and in breast cancer in particular.  We were among the first to describe the pivotal contribution of inflammatory chemokines to breast cancer development and progression.  By idenitifying the regulatory inflammation/immune-based networks, we will be able to propose novel therapeutics based on simultaneous targeting of several molecules, in a manner tailored to each patient. 

 

Recent Publications

Since 2007

 

S. Lerrer, Y. Liubomirski1, A. Bott, K. Abnaof, N. Oren, A. Yousaf, C. Körner, T. Meshel, S.  Wiemann, A. Ben-Baruch. Co-inflammatory roles of TGFβ1 in the presence of TNFα drive a pro-inflammatory fate in mesenchymal stem cells. Frontiers in Immunology. Accepted for publication.

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00479

 

A. Bott, N. Erdem, S. Lerrer, A. Hotz-Wagenblatt, C. Breunig, K. Abnaof, A. Wörner, H. Wilhelm, E. Münstermann, A. Ben-Baruch, S. Wiemann. miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget. Accepted for publication..

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=14915&pubmed-linkout=1

  

Weitzenfeld, T. Meshel, A. Ben-Baruch. Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells in Luminal-A breast tumor cells. Oncotarget. Vol .7, 2016 (pp 81123-81143).

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=13213&pubmed-linkout=1

 

D. Netanely, A. Avraham, A. Ben-Baruch, E. Evron, R. Shamir. Expression and methylation patterns partition Luminal-A breast tumors into distinct prognostic subgroups. Breast Cancer Res. Vol. 18, 2016 (pp. 74-89). 

 

P. Weitzenfeld, O. Kossover, C. Körner, T. Meshel, S. Wiemann, D. Seliktar, D.F. Legler, A. Ben-Baruch. Chemokine axes in breast cancer: Factors of the tumor microenvironment re-shape the CCR7-driven metastatic spread of luminal-A breast tumors. J Leuk. Biol. Vol. 99, 2016 (pp. 1009-1025). 

 

C. Katanov*, S. Lerrer*, Y. Liubomirski, L. Lieder-Trejo, T. Meshel, J. Bar, R. Feniger-Barish, I. Kamer, G. Soria-Artzi, H. Kahani, D. Banerjee#, A. Ben-Baruch#. Regulation of the inflammatory profile of stromal cells in human breast cancer: Prominent roles for TNFalpha and the NF-kappaB pathway. Stem Cell Research & Therapy. Vol. 1, 2015 (pp. 87-104). *Equal first authorship; #Equal last authorship, Ben-Baruch – Corresponding author.

 

Y. Lebel-Haziv, T. Meshel, G. Soria, A. Yeheskel , E. Mamon, A. Ben-Baruch. Breast cancer: Coordinated regulation of CCL2 secretion by intracellular glycosaminoglycans and chemokine motifs. Neoplasia. Vol. 16, 2014 (pp. 723-740).

 

T. Leibovich-Rivkin, Y. Liubomirski, T. Meshel, A. Abashidze D. Brisker, H. Solomon, V. Rotter, M. Weil, A. Ben-Baruch. The inflammatory cytokine TNFa cooperates with hyper-activated Ras in promoting metastasis and turns WT-Ras into an oncogenic entity in MCF-7 cells. BMC Cancer. Vol. 14, 2014 (pp. 158-176). 

 

P. Weitzenfeld, A. Ben-Baruch. The chemokine system, and its CCR5 and CXCR4 receptors, as potential targets for personalized therapy in cancer. Cancer Letters. Vol. 352, 2014 (pp. 36-53).

 

F. Bachelerie, A. Ben-Baruch*, A.M. Burkhardt, C. Combadiere, J.M. Farber, G. J. Graham, R. Horuk, A.H. Sparre-Ulrich, M. Locati, A.D. Luster, A. Mantovani, K. Matsushima, P.M. Murphy, R. Nibbs, H.  Nomiyama, C.A. Power, A.E. I. Proudfoot, M.M. Rosenkilde, A. Rot, S. Sozzani, M. Thelen, O. Yoshie, A. Zlotnik. Update on the Extended Family of Chemokine Receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacological Reviews. Vol. 66, 2014 (pp. 1-79). 

*Equal contribution of all authors (arranged by alphabetical order).

 

T. Leibovich-Rivkin, Y. Liubomirski, B. Bernstein, T. Meshel, A. Ben-Baruch. Inflammatory factors of the tumor microenvironment induce plasticity in non-transformed breast epithelial cells: EMT, invasion and collapse of normally-organized breast textures. Neoplasia. Vol. 15, 2013 (pp. 1330-1346).

 

P. Weitzenfeld, N. Meron, T. Leibovich-Rivkin, T. Meshel, A. Ben-Baruch. Progression of luminal breast tumors is promoted by Ménage-a-trois between the inflammatory cytokine TNFa and the hormonal and growth-supporting arms of the tumor microenvironment. Mediators of Inflammation. Vol. 2013, 2013 (Article ID. 720536).

 

G. Soria, Y. Lebel-Haziv, M. Ehrlich, T. Meshel, E. Avezov, P. Rozenberg, A. Ben-Baruch. Mechanisms regulating the secretion of the pro-malignancy chemokine CCL5 by breast tumor cells: CCL5’s 40s loop and intracellular glycosaminoglycans.Neoplasia. Vol. 14, 2012 (pp. 1-19). 

 

T. Leibovitz-Rivkin, Y. Buganim, H. Solomon, T. Meshel, V. Rotter, A. Ben-Baruch. Tumor-promoting circuits that regulate a cancer-related chemokine cluster: Dominance of inflammatory mediators over oncogenic alterations. Cancers. Vol. 4, 2012 (pp. 55-76).

 

T. Leibovitch-Rivkin, Y. Lebel-Haziv*, S. Lerrer*, P. Weitzenfeld*, A. Ben-Baruch. The versatile world of inflammatory chemokines in cancer. In: “The Tumor Immunoenvironment”. M.R. Shurin, V. Umansky, A. Malyguine, (Editors) Springer Publishers. 2012.

*Equal contribution.

 

A. Ben-Baruch. The tumor-promoting flow of cells into, within and out of the tumor site: Regulation by the inflammatory axis of TNFa and chemokines. Cancer Microenvironment. Vol  5, 2012 (pp. 151-164).

 

A. Ben-Baruch. Editor of a Review eBook, entitled "The inflammatory milieu of tumors: Cytokines and chemokines that affect tumor growth and metastasis". Bentham Science Publishers. 2012.

 

A. Ben-Baruch. The Inflammatory CC Chemokines CCL2 and CCL5 in Malignancy: Leukocyte migration and beyond. Published in: "The inflammatory milieu of tumors: Cytokines and chemokines that affect tumor growth and metastasis". A. Ben-Baruch (Editor). Bentham Science Publishers. 2012.

 

Z. Shulman, S.J. Cohen, B. Roediger, V. Kalchenko, R. Jain, V. Grabovsky, E. Klein, V. Shinder, L.  Stoler-Barak, S.W. Feigelson, T. Meshel, S. M. Nurmi, I. Goldstein, O. Hartley, C.G. Gahmberg, A. Etzioni, W. Weninger, A. Ben-Baruch, R. Alon. Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than extracellular chemokine depots. Nature Imm. Vol. 13, 2011 (pp. 67-76).

 

G. Soria, M. Ofri-Shahak, I. Haas, N. Yaal-Hahoshen, L. Leider-Trejo, T. Leibovich-Rivkin, P. Weitzenfeld, T. Meshel, E. Shabtai, , M. Gutman, A. Ben-Baruch.Inflammatory mediators in breast cancer: Coordinated expression of TNFa & IL-1b with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition. BMC Cancer. Vol. 11, 2011 (pp. 130-149).

 

K. Haim, P. Weitzenfeld, T. Meshel, A. Ben-Baruch. EGF and estrogen act by independent pathways to additively promote the release of the angiogenic chemokine CXCL8 by breast tumor cells. Neoplasia. Vol. 13, 2011 (pp. 230-243).

 

R. Mintz, B. Garty, T. Meshel, N. Marcus, C. Katanov, E. Cohen-Hillel, A. Ben-Baruch. Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients. Imm. Letters. Vol. 130, 2010 (pp. 97-106).

 

B. Garty, A. Ben-Baruch, A. Rolinsky, C. Woellner, B. Grimbacher, N. Marcus. Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome. Eur. J. Pediatrics. Vol. 169, 2010 (pp. 35-37).

 

Cohen-Hillel, T. Meshel, R. Mintz, B.-Z. Garty, A. Ben-Baruch. Cell migration to the chemokine CXCL8: Paxillin is activated and regulates adhesion and cell motility. Cell Mol. Life Sciences. Vol. 66, 2009 (pp. 884-899).

 

Soria, T. Meshel, A. Ben-Baruch. Chemokines in human breast tumor cells: Modifying their expression levels and determining their effects on the malignancy phenotype. Methods Enzymol. Vol. 460, 2009 (pp. 3-16).

 

I. Nevo, O. Sagi-Assif, T. Meshel, A. Ben-Baruch, K Jöhrer, R. Greil, L.E. Leider Trejo, O. Kharenko, M. Feinmesser, I. Yron, I.P. Witz. The involvement of the fractalkine receptor in the trans migration of neuroblastoma cells through bone marrow endothelial cells. Cancer Letters. Vol. 273, 2009 (pp. 127-139).

 

A. Ben-Baruch. Site-specific metastasis formation: Chemokines as regulators of tumor cell adhesion, motility and invasion. Cell Adhesion & Migration. Vol. 3, 2009 (pp 328-333).

 

A. Ben-Baruch. Topic Page. Chemokines in malignancy: Multifaceted roles and implications in tumor growth and metastasis. Elsevier’s Scirus Electronic Page. 2009.

 

A. Ben-Baruch. Editor of a Review Book: Breast cancer: From pathogenesis to potential therapeutic modalities. In: "Clinical Cancer Research". A. Ben-Baruch (Editor), Transworld Research Network. 2009.

 

G. Soria and A. Ben-Baruch. The CCL5/CCR5 axis in cancer. In: Book Series "Cancer Drug Discovery and Development - Chemokine Receptors in Cancer” A. Fulton (Editor). Springer Publishers. 2009 (pp. 109-130).

 

P. Mishra, D. Banerjee, A. Ben-Baruch. Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy.   J. Leuk. Biol. Vol. 89, 2011 (pp. 31-39). 

 

Soria, N. Yaal-Hahoshen, E. Azenshtein, S. Shina, L. Leider-Trejo, L. Rivo, E. Cohen-Hillel, A. Shtabsky, M. Ehrlich, T. Meshel, I. Keydar, A. Ben-Baruch. Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: A basis for tumor-promoting interactions. Cytokine. Vol. 44, 2008 (pp. 191-200).

 

H. Attal, E. Cohen-Hillel, T. Meshel, J.M Wang, W. Gong, A. Ben-Baruch. Intracellular cross-talk between the GPCR CXCR1 and CXCR2: Role of carboxyl terminus phosphorylation sites. Exp. Cell. Res. Vol. 314, 2008 (pp. 352-365).

 

G. Soria and A. Ben-Baruch. The inflammatory chemokines CCL2 and CCL5 in breast cancer. Cancer Letters. Vol. 267, 2008 (pp. 271-285).

 

A. Ben-Baruch. Organ selectivity in metastasis: Regulation by chemokines and their receptors. Clin. Exp. Metastasis. Vol. 25, 2008 (pp. 345-356).

 

A. Ben-Baruch. Expert commentary: The chemokine receptor CXCR3 and its ligands in malignancy: Do they act as double-edged swords? In: "Chemokine Research Trends". L.R Grinwald (Editor). Nova Science Publishers. 2008.

 

A. Zipin-Roitman, T. Meshel, O. Sagi-Assif, B. Shalmon, C. Avivi, R.M. Pfeffer, I.P. Witz, A. Ben-Baruch. CXCL10 promotes invasion-related properties in human colorectal carcinoma cells. Cancer Res. Vol. 67, 2007 (pp. 3396-3405).

 

E. Cohen-Hillel, I. Yron, T. Meshel, A. Ben-Baruch.The chemokine interleukin 8 and cell migration to inflammatory sites: The regulation of Focal Adhesion Kinase under conditions of migratory desensitization. IMAJ. Vol. 9, 2007 (pp. 579-583).

 

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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