Dr. Aminadav Yawetz

ביה"ס לזואולוגיה בדימוס
Dr. Aminadav Yawetz
Phone: 03-6408004
External phone: 09-7456292
Fax: 03-6407304
Office: Sherman - Life Sciences, 209



Ph. D. Biology University 1975-1977
M. Sc. Biology Tel Aviv University, Israel 1970-1973
B. Sc. Biology Tel Aviv University, Israel 1966-1969



Academic Appointments:

1994-2000 Principle research associate at the Institute for Nature Conservation Research at the Tel Aviv University.
1984-1994 Senior researcher at the Institute for Nature Conservation Research at the Tel Aviv University.
1979-1984 Researcher at the Institute for Nature Conservation Research at the Tel Aviv University.
1975-1977 Assistant at the Zoology Dep. at the Tel Aviv University
1969-1975 Researcher at the Inst. For Biol. Control


Research Interests

My scientific research work is in the field of biochemical environmental toxicology. It is focused on the study of cytochromes P450, acetylcholinesterase, phase II detoxifying enzymes in wildlife. Major attention is given to the interaction of environmental pollution with reproduction of marine and terrestrial organisms. My lab also developes methods and technology for the detection of low levels of organophosphorus and carbamate residues in fresh water.  Research activities include:

  • Study of cytochromes P450 in species of different Phyla.  
  • The interaction of environmental pollution with reproduction.
  • The development of biochemical method for the detection of low levels of organophosphorus and carbamate insecticides in fresh water using acetylcholinesterase profile in fish.


Recent Publications

Chapters in Books

Goldman, D. and Yawetz, A. 1989. PCB-induced alteration of steroid hormone biosynthesis in guinea-pig adrenal microsomes. In: Schuster, I. (ed.), "Cytochrome P-450: Biochemistry and Biophysics". P:833-836, Taylor and Francis, London.

Dotan, A., Zook-Rimon, Z. Yawetz, A. and Fishelson L. 1989. The Ecology of the glossy ibis ( Plegadis falcinellus ) near Akko (northern Israel), inassociation with anthropogenic food sources.

In: Spanier, E., Y. Steinbergerand M. Luria (eds.). "Environmental Quality and EcosystemStability", Vol IV-B:381-389. ISEEQS Pub., Jerusalem, Israel..

Yawetz, A , Zook-Rimon, Z. and Dotan, A. 1989. The use of cholinesterase activity and inhibition kinetics to monitor environmental stress on wildlife by organophosphorous and carbamate insecticides. In: Spanier, E., Y. Steinberger and M. Luria, (eds.) "Environmental Quality and Ecosystem Stability", Vol IV-B:487-496. ISEEQS Pub.,Jerusalem,Israel.

Goldman, D. and Yawetz, A. 1989. Effect of exposure to Aroclor 1254 on cytochrome P-450 mediated metabolism ofprogesterone by adrenal microsomes of male and female guinea-pigs.

In: Spanier, E., Y. Steinberger and M. Luria, (eds.) "Environmental Quality and Ecosystem Stability", Vol IV-B:497-506. ISEEQS Pub., Jerusalem, Israel.

Oron, U., Alter, A., and Yawetz, A. 1984. Corrosion in metal implants and its possible effect on hepatic cytochrome P-450. In: "Advances in Biomaterials", Vol V:233-235, Elsevier Science Publishers B.V., Amsterdam.

Kumburov, S.S., Yawetz, A. and Nadel, D.J. 1975. Application of the sterile-insect technique for control of Mediterranean fruit flies in Israel under field conditions. In: "Controlling Fruit flies bySterile-Insect-Technique", STI-BUB-392, P: 67-76.




Fishelson, L., Bressler V., Manelis, R. and Yawetz A. (submitted). Early warning responses associated with exposure of the bivalve Donax trunculus to marine pollution. Journal of Toxicology and Environmental Health.

Yawetz, A., Agosin, M., and Perry, A.S. 1978. Components of the electron transport system in the mixed-function-oxidase system in wild birds. Pest. Biochem. Phys, 8: 44-52.

Yawetz, A., Agosin, M. and Perry, A.S. 1978. Spectral and catalytic properties of cytochrome P-450 from four wild bird species. Comp. Biochem. Phys. 59C:45-49.

Yawetz, A., and Agosin, M. 1979. Epoxide hydrase in Trypanosoma cruzi epimastigots. Biochim. Biophys. Acta, 585:210-219.

Yawetz., A. Agosin, M., and Perry, A.S. 1979. Metabolism of Parathion and brain cholinesterase inhibition in four species of wild birds. Pest. Biochem. Phys. 11:294-300.

Yawetz, A., and Agosin M. 1980. Partial purification of glutathione-s-aryl and epoxide transferase of Trypanosoma cruzi . In: "Microsomes, Drug Oxidation, and Chemical Carcinogenesis". P:691-694, Academic Press Inc.

Yawetz, A., and Agosin, M. 1980. Glutathione-s-transferase and drug metabolism inTrypanosoma cruzi :in vivo and in vitro formation of thioethers. Comp. Biochem. Phys. 66C:265-267.

Yawetz, A., and Agosin, M. 1981. Purification of the glutathione-s-transferase ofTrypanosoma cruzi . Comp. Biochem. Phys. 68B:237-243.

Yawetz, A., Sneh, B., and Oron, U. 1983. Purification and hydrophobic properties of the d-endotoxin in the parasporal crystalproduced by Bacillus thuringiensis var. entomocidus .J. Invertebr. Pathol. 42:106-112.

Yawetz, A., Sidis, I., and Gasith, A. 1983. Metabolism of parathion and brain cholinesterase inhibition in Aroclor 1254-treated and untreated Caspian terrapin (Mauremys caspica rivulata, Emydidae, Chelonia) incomparison with two species of wild birds. Comp. Biochem. Phys. 75C:377-382.

Yawetz, A., Perry, A.S., Freeman, A, and Katchalski-Katzir, E. 1984. Monooxygenase activity of rat liver microsomes immobilized by entrapment in acrosslinked prepolimerized polyacrylamide hydrazide. Biochim. Biophys. Acta, 798:204-209.

Yawetz, A., and Koren, B. 1984. Purification and properties of the Mediterranean fruit flyCeratitis capitata W. glutathione-s- transferase. Insect Biochem. 14(6):663-670.

Koren, B., Yawetz, A., and Perry, A.S. 1984. Biochemical properties characterizing the development of tolerance to malathion in Ceratitis capitata Wiedemann (Diptera: Tephritidae). J. Econ. Entomol. 77(4):864-867.

Broza,M.,Sneh,B., Yawetz,A., Oron,U.,and Honigman, A. 1984. Comercial application ofBacillus thuringiensis var.entomocidus to cotton fields for the control of the Egyptian cotton leafworn, Spodoptera littoralis Boisd. (Lepidoptera, Noctuidae).J. Econ. Entomol. 77:1530-1533.

Yawetz, A., Alter, A., and Oron, U. 1984. Biochemical and hystological anomalities in the rat hepatic tissue following administration ofbichromate and nickel in ionized form. Toxicology 33:145-155.

Oron, U., Yawetz,A., Broza,M,Sneh,B, and Honigman, A. 1985. Ultrastructural changes in the larval midgut epitheliumof Spodoptera litoralis following ingestion ofd- endotoxin ofBacillus thuringiensis var entomocidus . J. Invertebr. Pathol, 45:353-355.

Honigman, A., Nedjar-Pazerin, G., Yawetz, A., Oron, U.,Schuster, S., Broza, M. and Sneh, B. 1986. Cloning and expression of the Lepidopteran toxin produced by Bacillus thuringiensis in Escherichia coli . Gene, 42:69-77.

Yunovitz, H.,Sneh, B., Schuster, S., Oron, U., Broza, M. and Yawetz, A. 1986. A new and sensitive method for determining the toxicity of a highly purified fraction from d- endotoxin produced by Bacillus thuringiensis var entomocidus on isolated larval midgut of Spodoptera littoralis (Lepidoptera, Noctuidae).J. Invertebr. Pathol, 50:223-231.

Yunovitz, H., Sneh, B. and Yawetz, A. 1987. The pH characterizing the cytolytic activity ofBacillus thuringiensis d-endotoxin in the larvalepitheliumof Spodoptera littoralis. J. Invertebr. Pathol., 50:320-321.

Yunovitz, H. and Yawetz, A . 1988. Interaction between the delta-endotoxin produced byBacillus thuringiensis subsp. entomocidus and liposomes. FEBS Letters. 230 (1,2):105-108.

Yawetz, A., Katz, A. and Waldstein, E. 1989. Purification and properties of hepaticO 6 -methylguanine-DNA-methyltransferase in human hepatic tissue. Biochemical Medicine and Metabolic Biology, 41(3):177-183.

Yunovitz, H. and Yawetz, A. 1989. The interaction of the delta-endotoxin purified fromBacillus thuringiensis subsp. entomocidus with liposomes and midgut epithelium membranes from twoinsect species. Israel J. Entomol, 23:255-258.

Goldman, D. and Yawetz, A. 1990. The interference of Aroclor 1254 with progesterone metabolism in guinea-pig adrenal and testesmicrosomes. J. Biochem. Toxicol, 5(2):99-107.

Gophen, M., Cohen, A., Grinberg, K., Pokamunski, S., Nili, E., Wynne, D., Yawetz, A.,

Dotan, A., Zook-Rimon, Z., Ben-Shlomo, M. and Ortenberg, Z. 1991. Implications of botulism outbreak in gulls ( Larus ridibundus ) on the watershed management of lake Kinneret (Israel). Environ. Toxicol. Water Quality., 6:77-84.

Goldman, D. and Yawetz, A. 1991. Cytochrome P-450 mediated metabolism of progesterone by adrenal microsomes of PCB-treated and untreated barn owl ( Tyto alba ) and marsh turtle ( Mauremys caspica ) in comparison with the guinea-pig. Comp. Biochem. Physiol. [C]. 99(1-2), 1991 (pp. 251-255).

Goldman, D. and Yawetz, A. 1992. The interference of Aroclor 1254 with membraneregulation of the activities of cytochromes P-450 C21 and P-450 17OH,Lyasse in guinea-pig adrenal microsomes. J. Steroid Biochem. Molec. Biol., 42:37-47.

Yawetz A., Manelis R. and Fishelson L. 1992. The effects of Aroclor 1254 and petrochemical pollutants on cytochrome P450 from the digestive gland microsomes of four species of Mediterranean molluscs. Comp. Biochem. Physiol., 103C:607-614.

Manelis R., Fishelson L., Yawetz A., Harnug H. and Zuk- Rimon Z. 1992. Patella carulea(Gastropoda, Mollusca) as a key biomonitor for chemical and thermal pollution along therocky intertidal of the Israeli Mediterranean. Rapp. Comun. int. Mer Medit., 33:43.

Yawetz, A., Woodin, B.R.,Smolowitz, R.M. and Stegeman, J.J. 1992. Induction, fractionation and localization of cytochromeP450 isozymes in the liver of thefreshwater turtle Chrysemys picta picta . Marine Environmental Research.

Yawetz, A., Zok-Rimon, Z. and Dotan, A. 1993. Cholinesterase enzymatic profile in two species of wild birds exposed to insecticide sprays in their natural habitat. Archives Insect Biochem. Physiol., 22:501-509.

Yawetz, A., Goldman, D., Stegeman, J.J.,and Woddin, B. 1993. The effect of PCB on the induction of cytochrome P450 enzyme, detected by monoclonal antibodies against the P450IA1 gene family, in the barn owl and the marsh turtle hepatic microsomes. Wat. Sci. Tech., 27(7-8): 457-464.

Manelis, R., Hornung H., Fishelson, L., and Yawetz, A. 1993. The effects of exposure to heavy metals on cytochrom b 5 and components of the mixed-function-oxidases from the digestive gland microsomes of the mollusc Monodonta turbinata. Wat. Sci. Tech., 27(7-8):473-480.

Yawetz, A., Manelis, R., and Gasith, A. 1993. Cholinesterase enzymatic profiles and the exposure of fish to organophosphorous and carbamat pesticides in Israel. Wat. Sci. Tech., 27(7-8): 465-472.

Fishelson L., Yawetz A., Perry A.S., Zuk-Rimon Z.,Manelis R., Dotan A. 1994.The environmental health profile (EHP) for the Acre valley: xenobiotics in animals andphysiologicalevidence of stress. Sci. Total Environ., 144:33-45.

Yawetz A. , Zook-Rimon Z., Woodin B. and Stegeman J.J. 1994. Cytochrome P4501A1 induction and cholinesterase inhibition as a measure of exposure of gerbils to agricultural and industrial pollutants in the city ofAshdod, Israel. Human Experimental Toxicol., 9(3).

Fishelson L., Manelis R., Zuk-Rimon Z., Dotan A., HornugH. and Yawetz A. 1996. Ecology, enzymology and population dynamics of some selected littoral molluscsUNEP/FAO/MAP Technical Reports Series 103:57-73, UNEP Athens, Greece.

Yawetz,A., Benedek-Segal,M.,and Woodin B. 1997. Cytochrome CYP1A immunoassy in freshwater turtles and exposure to PCBs andEnvironmental pollutants. Environ. Toxicol. Chem. 16(9):1802-1806.

Yawetz,A., Woodin B.R. andStegeman, J.J. 1998. Cytochrome P450 (CYP) in liver of the turtle Chrysemys picta picta and the induction and partial purification of CYP1A-like proteins. Biochim. Biophys. Acta,, 1381:12-26).

Yawetz A. andZilberman, B. 1998. Cytochrome P4501A1 of Mugil capio and Mugil auratus, induction and partial purificationfrom liver and heart tissues. Marine Environmental Research, In Press.

Yawetz, A., Zilberman, B., Woodin, B.and Stegeman, J.J. 1998. CtochromesP4501A, P4503A, and P4502B in liver and heart of Mugil capio treated with CYP1A inducers. Emviron. Toxicol. Pharmacol., 6:13-25.

Fishelson, L., Bressler V., Manelis, R., Zuk-Rimon Z., Dotan, H. and Yawetz A. 1999. Toxicological aspects associated with the ecology of Donax trunculus (Bivalvia, Mollusca) in polluted environment. The Science of the Total Environment., 226:121-131. ABSTRACTS PRESENTED AT SCIENTIFIC MEETINGS

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