Prof. Iftach Nachman

School of Biochemistry Neurobiology Biophysics
Faculty of Life Sciences

בית הספר לנוירובילוגיה ביוכימיה וביופיזיקה סגל אקדמי בכיר

Email: iftachn@tauex.tau.ac.il

Phone: 03-6405900

Fax: 03-6409442

My CRIS profile

The Lab Site

Office: Sherman - Life Sciences, 506

Research Interests

The Nachman Lab focuses on understanding early developmental cell fate decisions and patterning at the phenotypic and mechanistic level. We use embryonic stem cell-based in-vitro models (including Gastruloids and Trunk-Like Structures), combining live cell imaging (e.g., two-photon microscopy), and advanced computational/statistical methods to investigate how signaling networks and intrinsic cellular properties govern robust developmental timing and fate choice.

Some recent and ongoing projects:

Initial symmetry breaking and mesendoderm differentiation
Onset and patterning of definitive endoderm
Effects of signal perturbations on advanced gut development
Effects of common teratogens (e.g. nicotine, caffeine) on early cardiac development
Embryo models in common livestock species (sheep, pig)

Selected Key Publications

A full list of publications is available on the Lab Website.

Farag N, Sacharen C, Avni L, Nachman I. (2024). Coordination between endoderm progression and mouse gastruloid elongation controls endodermal morphotype choice. Developmental Cell. S1534-5807(24)00335-6.
Hauser M, Zirman A, Rak R, Nachman I. (2024). Challenges and opportunities in cell expansion for cultivated meat. Frontiers in Nutrition. 11:1315555.
Pour M, Kumar AS, Farag N, et al., Nachman I. (2022). Emergence and patterning dynamics of mouse definitive endoderm. iScience. 25(1): 103556.
JV Veenvliet, PF Lenne, DA Turner, I Nachman, V Trivedi. (2021). Sculpting with stem cells: how models of embryo development take shape. Development. 148(24): dev192914.
Sagy N, Slovin S, Allalouf M, Pour M, Savyon G, Boxman J, Nachman I. (2019). Prediction and control of symmetry breaking in embryoid bodies by environment and signal integration. Development. 146 (20): dev181917.
Boxman J, Sagy N, Achanta S, Vadigepalli R, Nachman I. (2016). Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation. Scientific Reports. 6:31623.
Pour M†, Pilzer I†, Rosner R, Smith ZD, Meissner A, Nachman I. (2015). Epigenetic predisposition to reprogramming fates in somatic cells. EMBO Reports. 16(3): 370-378.
Smith ZD*, Nachman I*, Regev A, Meissner A. (2010). Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nature Biotechnology. 28(5): 521-6.
Nachman I, Regev A, Ramanathan S. (2007). Dissecting timing variability in yeast meiosis. Cell. 131(3): 544–556.