Prof. Isaac Barash

Emeritus in Molecular Biology Ecology of Plants
ביולוגיה מול.ואקול.צמחים אמריטוס
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Prof. Isaac Barash
Phone: 03-6406251
Fax: 03-6409380
Office: Britannia-Porter, 514


I. University Education

      1956-1961 –  The Hebrew University of Jerusalem,

      1961 – M.Sc. in Plant Protection

      1961-1965 – University of California, Davis, U.S.A.

      1965 – Ph.D. Plant Pathology (Biochemistry minor)


II. Research and Teaching Appointments

      1965-1967     University of California, Los Angeles, Acting Assistant Professor (in Medical Mycology), Department of Medical Microbiology and Immunology

      1967-date      Tel Aviv University, Israel, Department of Plant Sciences

      1982-date      Professor

      1980-84         Chairman, Department of Plant Sciences, Tel Aviv University

      1987-1992     Chairman, Department of Plant Pathology, Agricultural Research Organization, The Volcani Center

      1995-2000     Dean of the Faculty of Life Sciences, Tel Aviv University

      2000- 2005    Director of the Institute for Cereal Improvement

      2005-date      Professor Emeritus


III.   Memberships in Scientific Societies

      American Phytopathological Society  (Elected as an APS Fellow).

      International Society for Molecular Plant - Microbe Interactions

      Israeli Phytopathological Society

      International Society for Plant Molecular Biology


IV. Editorial and Manuscripts’ Reviews

      Editorial Boards: “Biology of metals” “Phytoparasitica.

      Reviewed manuscripts: “Molecular Plant-Microbe Interactions”, “Molecular Plant Pathology” “FEBS Letters” “Plant Science” “Phytopathology”.


V. Competitive Grants

Research was constantly supported by grants obtained from the “Binational Science Foundation,” (BSF), “Israeli Academy of Sciences,” (ISF), “Binational Agricultural Research and Development,” (BARD), “German Research Foundation (DFG) for trilateral  cooperative research between Israeli, Palestinian and German Scientists”, “USAID-CDR” (including cooperation with  Kazakhstan), “Agency for International Development, U.S.A”, (with Dr. Albert Afosu Asiedo - Ghana), “Israeli Ministry of Science” (including cooperation with Ukrine).


VI. Committees (partial list)

I had served as a member or a chair of numerous faculty, national and international committees including ISF (Israeli Science Foundation) commities, BARD (Binational, the “American Phytopathological Society Awards and Honors Committee (1999-2001).” (Chair-2001), Organizing Committees for International Symposia (e.g., Bat Sheva Senminar for host-fungus interactions, Technical Advisory Committee (TAC) of BARD, a member of the “20 Years Review Committee of BARD”,   Member and a chair of the “Committee for Promotion of scientists from government research institutes”.


VII Teaching

22  graduate students for a Ph.D. degree and 32 for M.Sc. degree have  completed their research in my laboratory. I have taught the following courses during the last 25 years prior to retirement: “Physiology of Fungi”, “Biology of Plant Pathogenic bacteria and Fungi” “Molecular Plant-Microbe Interactions” (advanced course). “Molecular aspects of Pathogenicity and symbiosis during the interaction between bacteria and plants” (advanced course).


Publications since retirement (out of 127):


Nissan, G., Manulis, S., Weinthal, D.M., Sessa, G. and Barash, I. 2005. Analysis of promoters recognized by HrpL, an alternative sigma factor protein from Pantoea agglomerans pv. gypsophilae. Mol. Plant-Microbe Interact. 18:634-643.


Barash, I. and S. Manulis. 2005. Hrp-dependent biotrophic mechanism of virulence-how it has evolved in tumorigenic bacteria? Phytoparasitica 33:317-324.


Barash I.,Panijel, M., Gurel, F., Chalupowicz, L. and  Manulis, S. (2005) Transformation of Pantoea agglomerans into a tumorigenic pathogen. In S. Sorvari  and O.Toldi, eds, Proceedings of the 1st International Conference on Plant-Microbe Interactions: Endophytes and Biocontriol Agents., Lapland, Finland: Saariselka, pp 10-19.


Chalupowicz, L., Barash, I., Schwartz, M., Aloni, R., Manulis, S. 2006.Comparative  anatomy of gall development on Gypsophila paniculata induced by bacteria with different mechanism of pathogenicity. Planta 224:429-437.


Nissan, G., Manulis, S., Weinthal, D., Mor, H., Sessa, G. and Barash, I. 2006 The type  III effectors HsvG and HsvB of gall-forming Pantoea agglomerans determine host specificityand function as transcriptional activators. Molecular Microbiology 61:1118-1131.


Barash, I. and Manulis-Sasson, S. 2007. Virulence mechanisms and host specificity of gall-forming Pantoea agglomeransTrends in Microbiology 15:538-545.


Weinthal, D.M., Barash, I., Panijel, M., Valinsky, L., Gaba, V. and Manulis-Sasson, S. 2007. Distribution and replication of the pathogenicity plasmid pPATH in diverse populations of the gall-forming Pantoea agglomerans. Applied and Environmental Microbiology 73:7552-7561.


Balaji, V., Jacob-Hirsh, J., Sherf, O., Eichenlaub, R., Iraki, N., Manulis-Sasson, S., Rechavi, G., Barash, I. and Sessa, G. 2008. Tomato transcriptome changes in response to Clavibacter michiganensis subsp. michiganensis reveal a role for ethylene in disease development. Plant Physiology 146:1797-1809.


Kleitman, F., Barash, I., Burger, A., Iraki, N., Falah, F., Sessa, G., Weinthal, D., Chalupowicz, L., Gartemann, K.-H., Eichenlaub, R. and Manulis-Sasson, S. 2008. Characterization of Clavibacter michiganensis subsp. michiganensis population in Israel. European journal of Plant Pathology (121:463-475).


Chalupowicz, L., Manulis-Sasson, S., Itkin, M., Sacher, A., Sessa, G. and Barash I. 2008. Quorum sensing system affects gall development incited by Pantoea agglomerans pv. gypsophilae. Molecular Plant Microbe Interactions 21:1094-1105.


Chalupowicz, L., Barash, I., Panijel, M., Sessa, G. and Manulis-Sasson, S. (2009). Regulatory interactions between quorum-sensing, auxin, cytokinin and the hrp regulon in relation to gall formation and epiphytic fitness of Pantoea agglomerans pv. gypsophilae. Molecular Plant-Microbe Interactions 22 :649-856.

Barash, I. and Manulis-Sasson, S. (2009). Recent evolution of bacterial pathogens: the gall-forming Pantoea agglomerans case. Annual Review of Phytopathology 47:133-152.


Chalupowicz, L., Cohen-Kandli M., Dror, O., Eichenlaub R., Gartemann K.-H. Sessa G., Barash I., Manulis-Sasson S. (2010) Sequential expression of  bacterial virulence and plant defense genes during infection of tomato with Clavibacter michiganensis  subsp. michiganensis. Phytopathology 100:252-261.


Weinthal D. M., Barash, I ., Tzfira, T., Gaba,V., Teper,D., Sessa, G. and Manulis-Sasson, S. (2011).  Characterization of nuclear localization signals in the type III effectors HsvG and HsvB of the gall-forming bacterium Pantoea agglomerans. Microbiology ; 157: 1500 – 1508.


Chalupowicz L, Zellermann E-M, Fluegel O, Dror O, Eichenlaub R, Gartemann, K-H, Savidoe, A, Sessa, G., Iraki, N., Barash I., Manulis-Sasson, S. (2012). Colonization and movement of GFP-labeled Clavibacter michiganensis subsp. michiganensis during tomato infection. Phytopathology 102:23-31.


Nissan, G., Manulis-Sasson, S., Chalupowicz, L., Teper D., Yeheskel, A., Pasmanik-Chor, M., Sessa, G. and Barash, I. (2012). The type III effector HsvG of the gall-forming Pantoea agglomerans mediates expression of the host gene HSVGT. Molecular Plant-Microbe Interactions 25 :231-240.


Chalupowicz ,L., Weinthal. D., Gaba, V., Sessa, G., Barash, I. and Manulis-|Sasson, S., 2013. Polar auxin transport is essential for gall formation by Pantoea agglomerans on  gypsophila. Mol. Plant Pathology, 14. 185-190.


Panijel, M., Chalupowicz, L., Sessa, G., Manulis-Sasson, S. and Barash, I. (2013). Global regulatory networks control the Hrp regulon of the gall-forming bacterium Pantoea agglomerans pv. gypsophilae. Molecular Plant-Microbe Interactions 26 :1031-1043.


Tancos, M.A., Chalupowicz, L., Barash, I., Manulis-Sasson, S. and Smart, C.D.   (2013). Tomato fruit and seed colonization by Clavibacter michiganensis subsp. michiganensis through external and internal routes. Applied and Environmental Microbiology 79:6948-6957.


Barash, I. 2014.  How way leads on to way. Annual Review of Phytopathology 52:1.1-1.17.


Savidor, A., Chalupowicz, L., Teper, D. , Gartemann, K-H., Eichenlaub, R., Manulis-   Sasson, S., Barash, I. and  Sessa, G. (2014). Clavibacter michiganensis subsp. michiganensis transcriptional regulators are required for virulence in tomato. Molecular Plant-Microbe Interactions 27:1035-1047.


Barel, V., Chalupowicz, L., Barash, I., sharabani, G., Reuven, M., Dror, O., Burdman, S., and Manulis-Sasson, S. 2015. Virulence and in planta movement of Xanthomonas hortorum pv. pelargonii are affected by diffusable signal factor (DSF)-dependent quorum sensing system. Molecular Plant Pathology


Chalupowicz, L., Barash, I., Reuven, M., Dror, O., Sharabani, G., Gartemann, K.-     H., Eichenlaub, R., Sessa, G. and Manulis-Sasson, S. (2017). Differential contribution of Clavibacter michiganensis subsp. michiganensis virulence factors to systemic and local infection in tomato. Molecular Plant Pathology 18:336-346.


Nissan, G., Gershovitz, M., Morozov, M., Chalupowicz, L., Sessa, G., Manulis Sasson, M., Barash, I. and Pupko, T. (2018)  Revealing the inventory of type III effectors in Pantoea agglomerans gall-forming pathovars using draft genome sequences and a machine-learning approach. Molecular Plant Pathology 19:381-392.                            


Chalupowicz, L., Nissan, G., Brandl, M. T., McClelland, M., Sessa, G., Popov, G.,   Barash, I., Manulis-Sasson, S. (2018).  Assessing the ability of Salmonella enterica to translocate type III effectors into plant cells. Molecular Plant-Microbe Interactions     31:233-239.


Nissan, G. Chalupowicz, L., Sessa, G., Manulis-Sasson, S., Barash, I. (2019). Two Pantoea agglomerans type III effectors can transform nonpathogenic and phytopathogenic bacteria into host-specific gall-forming pathogens. Molecular Plant Pathology   20:1582-1587.

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