Dr. Lior Mayo

Faculty of Life Sciences
מנהלת הפקולטה למדעי החיים

Research Interests

Our lab strives to understand better the underlying mechanisms that drive autoimmunity and neuroinflammation and to translate that knowledge into meaningful medical advances.

Our research comprises basic and translational programs aiming to elucidate the molecular immunometabolic mechanisms of intracellular communication that drive neurologic disorders (ranging from autoimmune and degenerative diseases to cancer).

We are particularly interested in:

  • Elucidate the immune function of the different glia, mainly astrocytes, and NG2-glia cells in disease.
  • Investigate the immunometabolic response in the brain.
  • Study the crosstalk between the innate and adaptive immune systems in the central nervous system.
  • Exploring the immunological aspects of the astrocyte-neuron relationship.
  • Developing novel strategies for targeting dusrutice processes in brain disorders, and identify novel diagnostic markers


Our research combines state-of-the-art technologies such as genome-wide sequencing, genomic editing, molecular imaging, targeted and un-targeted mass-spectrometry and real-time metabolic analysis.



Selected publications

Meyer T^, Shimon D^, Youssef S, Yankovitz G, Tessler A, Chernobylsky T, Gaoni-Yogev A, Perelroizen R, Budick-Harmelin N, Steinman L, Mayo L*. NAD+ metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity. PNAS 2022

Perelroizen R^, Philosof B^, Budick-Harmelin N, Chernobylsky T, Ron A, Rotem K, Shimon D, Tessler A, Adir O, Gaoni-Yogev A, Meyer T, Krivitsky A, Shidlovsky N, Madi A, Ruppin A, Mayo L. Astrocyte immunometabolic regulation of the tumor microenvironment drives glioblastoma pathogenicity. Brain 2022 (ahead of print, https://doi.org/10.1093/brain/awac222).

Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC,Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ*. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell 2019. 179 (7), 1483-1498. e22

Benbenishty A, Gadrich M, Cottarelli A, Lubart A, Kain D, Amer M, Shaashua L, Glasner A, Erez N, Agalliu D, Mayo L, Ben-Eliyahu S*, Blinder P*. Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation. PLoS Biol. 2019 Mar 28;17(3).

Frishberg A, Peshes-Yaloz N, Cohn O, Rosentul D, Steuerman Y, Valadarsky L, Yankovitz G, Mandelboim M, Iraqi FA, Amit I, Mayo L, Bacharach E, Gat-Viks I*. Cell composition analysis of bulk genomics using single-cell data. Nat Methods. 2019 Apr;16(4):327-332.

Steuerman Y, Cohen M, Peshes-Yaloz N, Valadarsky L, Cohn O, David E, Frishberg A, Mayo L, Bacharach E, Amit I, Gat-Viks I*. Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing. Cell Syst. 2018 Jun 27;6(6):679-691

Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL*. Acute microglia ablation induces neurodegeneration in the somatosensory system. Nat Commun. 2018 Nov 1;9(1):4578

Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ*. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 May;22(5):729-740.

Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan J, Pasparakis M, Kelliher MA, Ravits J & Yuan J*. RIPK1 Mediates Axonal Degeneration by Promoting Inflammation and Necroptosis in ALS. Science. 2016 Aug 5; 353(6299):603-8

Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL*. IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain. 2016 Jul;139(7):1939-1957.
This work was highlighted by Winger RC and Zamvil SS. Your nose knows how to target brain inflammation. Brain. 2016 Jul;139(Pt 7):1866-9

Rothhammer V, Mascanfroni DI, Bunse L, Takenaka M, Kenison J, Mayo L, Chao C, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ*. Modulation of astrocyte activity by type I interferon and dietary tryptophan limits inflammation in the central nervous system Nat Med. 2016 Jun;22(6):586-597. [journal ranking # 1/123 [Medicine, research and experimental, IF=87.241, journal ranking # 1/139 (Q1, Top 10%), cited: 613]

This work was highlighted by:
•    Bray N. Glia: An astrocytic axis. Nat Rev Neurosci. 2016 Jul;17(7):398-9.
•    Marsland BJ. Regulating inflammation with microbial metabolites. Nat Med. 2016 Jun 7;22(6):581-3

Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ*. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct;20(10):1147-56. [Medicine, research and experimental, IF=87.241, journal ranking # 1/139 (Q1, Top 10%), cited: 255]

This work was highlighted by:
•    Whalley K. Neurodegeneration: Active astrocytes drive inflammation. Nat Rev Neurosci. 2014 Oct; 15: 698.
•    Rostami, A., & Ciric, B. Astrocyte-derived lactosylceramide implicated in multiple sclerosis. Nat Med. 2014 Oct; 20(10), 1092–1093

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