Prof. Moshe Mevarech

Emeritus in Biotechnology
מקרוביולוגיה מולקולרית אמריטוס



1969 B.Sc. Hebrew University, Jerusalem
1972 M.Sc Weizmann Institute, Rehovot, Israel
1977 Ph.D. Weizmann Institute, Rehovot, Israel
1977-80 Postdoctural Fellow, University of Chicago, Chicago, Illinois, USA


Academic Positions

1980-85 Lecturer, Dept. Microbiology and Immunology, TAU
1985-90 Senior Lecturer, Dept Microbiology and Immunology, TAU
1990- Assoc. Professor, Dept of Mol. Microbiology & Biotechnology, TAU


Other Appointments

1986 Visiting Professor, Dept. Microbiology, University of Alberta, Edmonton, Canada
1991 Visiting scientist, Max-Planck Institute for Biochemistry, Martinsried, Germany
1997 Visiting scientist, Millennium Pharmaceuticals Inc., Cambridge, MA, USA


Research Interests

My research interests are: 

  • The mechanism of the natural genetic exchange system of Haloferax volcanii.
  • Understanding the mode of adaptation of halophilic enzyme to function at extremely high salt concentrations.
  • Study bacteriorhodopsin biogenesis.
  • Developing genetic tools for Hf. volcanii.
  • Quorum sensing in halophilic archaea.


Recent Publications

Publications in refereed journals

Rosenbluh, A., Mevarech, M., Koltin, Y. and Gorman, J. (1985). Isolation and expression of genes of Candida albicans by complimentation in Sacchromyces cerevisiae. Mol. Gen. Genet. 200: 500-502


Mevarech, M. and Werczberger, R. (1985). Genetic transfer in Halobacterium volcanii. J. Bacteriol. 162: 461-452


Rosenshine, I., Zusman, T., Werczberger, R. and Mevarech, M. (1987). Amplification of specific DNA sequences correlates with resistance of the archaebacterium Halobacterium volcanii to the dihydrofolate reductase inhibitors trimethoprim and methotrexate. Mol. Gen. Genet. 208: 518-522


Leskiw, B.K., Aharonowitz, Y., Mevarech, M., Wolf, S., Vining, L.C., Westlake, D.W.S. and Jensen, S. (1988). Cloning and sequence determination of the isopenicillin N synthetase gene from Streptomyces clavuligerus. Gene 62: 187-196


Shiffman, D., Mevarech, M., Jensen, S.E., Cohen, G. and Aharonowitz, Y. (1988) Cloning and comparitive sequence analysis of the gene coding for isopenicillin N synthase in Streptomyces. Mol.Gen. Genet. 214: 562-573


Harel, M., Shoham, M., Frolow, F., Eisenberg, H., Mevarech, M., Yonath, A. and Sussman, J.L. (1988) Crystallization of halophilic malate dehydrogenase from Halobacterium marismortui. J. Mol. Biol. 200: 609-610.


Rosenshine, I. and Mevarech, M. (1989) Isolation and partial characterization of plasmids found in three Halobacterium volcanii isolates. Can. J. Microbiol. 35: 92-95.


Reddy, P.G., Allon, R., Mevarech, M., Mendelovitz, S., Sato, Y. and Gutnick D.L. (1989) Cloning and expression in E. coli of an esterase gene from the oil degrading bacterium Acinetobacter calcoaceticus RAG-1. Gene 76: 145-152.


Mevarech, M., Hirsh-Twizer, S., Goldman, S., Yakobson, E., Eisenberg, H. and Dennis, P.P. (1989) Isolation and characterization of the rRNA gene clusters of Halobacterium marismortui. J. Bacteriol. 171: 3479-3485.


Rosenshine, I., Tchelet, R. and Mevarech, M. (1989) The mechanism of DNA transfer in the mating system of an archaebacterium. Science 245: 1387-1389.


Zusman, T., Rosenshine,I., Boehm, G., Jaenicke, R. and Mevarech, M. (1989) Dihyrofolate reductase of the extremely halophilic archaebacterium Halobacterium volcanii. J. Biol. Chem. 264: 18878-18883.


Shiffman, D., Cohen, G., Aharonowitz, Y., Palisa, H., von Dohren, H., Kleinkauf, H., Mevarech, M. (1990) Nucleotide sequence of the isopenicillin N synthase gene (pcbC) of the gram negative Flavobacterium sp. SC 12,154. Nucleic Acids Research 18: 660.


Cohen, G., Shiffman, D., Mevarech, M. and Aharonowitz, Y. (1990) The microbial isopenicillin N synthase genes: structure, function,diversity and evolution. Tends in Biotechnology 8: 105-111.


Leskiw, B.K., Mevarech, M., Barrit, L.S., Jensen, S.E., Henderson, D.J., Hopwood, D.A., Bruton, C.J. and Chater, K.F. (1990) Discovery of an insertion sequence from Streptomyces clavuligerus and its relatedness to two transposable elements of Streptomyces coelicolor. J. Gen. Microbiol. 136: 1251-1258.


Goldman,S., Hecht, K., Eisenberg, H. and Mevarech, M. (1990) Extracellular Ca++ Dependent Inducible Alkaline Phosphatase from the Extreme Halophilic Archaebacterium Haloarcula marismortui. J. Bacteriol. 172: 7065-7070.


Cendrin, F., Chroboczek, J., Zaccai, G., Eisenberg, H. and Mevarech, M. (1993) Cloning, Sequencing and Expression in Escherichia coli of the Gene Coding for Malate Dehydrogenase of the Extremely Halophilic ArchaebacteriumHaloarcula marismortui. Biochemistry 32: 4308-4313. medline


Daniel, E., Azem, A., Shaked, I. and Mevarech, M. (1993) Subunit Structure of Halophilic Malate Dehydrogenase fromHaloarcula marismortui. Comp. Biochem. Biophys. 106: 401-405.


Blecher, O., Goldman, S. and Mevarech, M. (1993) High expression in Escherichia coli of the gene coding for dihydrofolate reductase of the extremely halophilic archaebacterium Haloferax volcanii. Reconstitution of the active enzyme and mutation studies. Eur. J. Biochem. 216: 199-203. medline


Tchelet, R. and Mevarech, M. (1994) Interspecies Genetic Transfer in Halophilic Archaebacteria. Syst. Appl. Microbiol. 16: 578-581.


Dym, O., Mevarech, M. and Sussman, J. L. (1995) Structural Features that Stabilize Halophilic Malate Dehydrogenase from an Archaebacterium. Science 267: 1344-1346.


Frolow, F., Harel, M., Sussman, J.L., Mevarech, M. and Shoham, M. (1996) Protein adaptation to a saturated salt environment: Insights from the crystal structure of a halophilic 2Fe-2S ferredoxin. Nature Struc. Biol. 3:451-457.medline


Yaar, L., Mevarech, M. and Koltin, Y. (1997) A Candida albicans RAS related (CaRSR1) gene is involved in budding, cell morphogenesis, and hyphae development. Microbiology 143:3033-3044.


Pieper, U., Kapadia, G., Mevarech, M. and Herzberg, O. (1998) . Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii. Structure 6: 75-88. medline


Nomura, S., Kajimura, N., Matoba,. K., Miyata, T., Ortenberg,. R., Mevarech, M., Kamikubo, H., Kataoka, M. and Harada, Y. (1999) Ordered Structure Formation of Bacteriorhodopsin-hDHFR in a Plasma Membrane. Langmuir 15: 214-220.


Madern, D., Ebel, C., Mevarech, M., Richard, S.B., Pfister, C. and Zaccai, G. (2000) Insights into the molecular relationships between malate and lactate dehydrogenases: Structural and biochemical properties of monomeric and dimeric intermediates of a mutant of tetrameric L-[LDH-like] malate dehydrogenase from the halophilic archaeonHaloarcula marismortui. Biochemistry 39:1001-1010. medline


Ortenberg, R., Rozenblatt-Rosen, O. and Mevarech, M. (2000) The extremely halophilic archaeon Haloferax volcaniihas two very different dihydrofolate reductases. Molec. Microbiol. 35: 1493-1505. medline


Mevarech, M., Frolow, F. and Gloss, L.M. Halophilic enzymes: proteins with a grain of salt. Biophys. Chem., In Press.


Ortenberg, R. and Mevarech, M. Evidence for post-translational membrane insertion of the integral membrane protein bacterioopsin expressed in the heterologous halophilic archaeon Haloferax volcanii. J. Biol. Chem. In Press. medline



Chapters in books

Zusman, T. and Mevarech, M. (1991) Biochemical characterization of dihydrofolate reductase of Halobacterium volcanii. In: General and Applied Aspects of Halophilic Microorganisms. F. Rodriguez-Valera ed., pp. 181-187, Plenum Press, New York.


Rosenshine, I. and Mevarech, M. (1991) The kinetics of the genetic exchange process in Halobacterium volcaniimating. In: General and Applied Aspects of Halophilic Microorganisms. F. Rodriguez-Valera ed., pp. 265-270, Plenum Press, New York.


Eisenberg, H., Mevarech, M. and Zaccai, G. (1992) Biocemical, Structural and Molecular Genetic Aspects of Halophilism. Adv. Prot. Chem. 43, 1-61.


Ortenberg, R. Tchlet, R., and Mevarech, M. (1998) A Model for the Genetic Exchange System of the Extremely Halophilic Archaeon Haloferax volcanii. In: Microbiology and Biogeochemistry of Hypersaline Environments. (A. Oren ed.) CRC Press. pp. 331-338


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