Prof. Michael Gurevitz

ביולוגיה מול.ואקול.צמחים אמריטוס
Quick navigation:
Prof. Michael Gurevitz
Phone: 03-6409844
External phone: 09-7717160
Fax: 03-6406100
Office: Britannia-Porter, 505

CV

Education

Period Degree Institute Faculty/Department
1967-1969 B.Sc. Hebrew Univ. Jerusalem Microbiology & Zoology
1970-1972 M.Sc. Hebrew Univ. Jerusalem Entomology
1975-1980 Ph.D. Hebrew Univ. Jerusalem Biological Chemistry

 

Further Studies

Period Rank/Function Institute Faculty/Department
1981-1983 Research Associate Washington Univ. Medical School, St. Louis, MO, USA Dept. Microbiology & Immunology (RNA processing in prokarytes)
1984-1986 Research Associate Michigan State Univ., East Lansing, MI, USA Plant Research Laboratory (Interaction of nuclear and organelle genomes)

 

Employment

Period Rank/Function School/Department Institute
1972-1974 Research Assistant Dept. of Molec. Biol (Prof. N. Zitri: Production and purification of Penicilinase) Hadassah Medical School, Jerusalem
1981-1983 Research Associate Dept. Microbiology & Immunology (RNA processing) Washington Univ. Medical School, St. Louis, MO, USA
1984-1986 Research Associate PRL (Cyanobacterial and Rubisco molecular genetics) Michigan State Univ., East Lansing, MI
1987-1991 Senior Lecturer Faculty of Life Sciences, Dept. of Botany
1. Cyanobacterial and Rubisco molecular biology
2. Genetic approach to the utilization of anti-insect selective neurotoxins for the design of novel insecticides.
Tel-Aviv Univ.
1992-1994 Senior Researcher Faculty Life Sciences, Dept. Botany Tel-Aviv Univ.
1994-1999 Associate Professor Faculty Life Sciences, Dept. Plant Scienecs Tel-Aviv Univ.
1999- Professor Faculty Life Sciences, Dept. Plant Scienecs Tel-Aviv Univ.

 

Teaching Experience

Year Name of Course Organizer
1971 Physiology of Insects Prof. E. Zlotkin
1972 Zoology: Vertebrates & Invertebrates Dr. R. Lotan-Shiloh & Prof. E. Zlotkin
1976 Introduction to Biochemistry Prof. A. Hochberg
1977 Introduction to Ecology Prof. M. Shiloh & Prof. D. Zohari
1977 Dynamic Biochemistry Prof. N. de-Groot
1978 Biotechnology Dr. S. Bauer
1979 Subcellular Organelles Prof. I. Ohad
1987-1989 Molecular Biology of Plants and Cyanobacteria Dr. A. Breiman, Dr. A. Zilberstein, Dr. M. Gurevitz
1987, 1988 "New Horizons" Prof. B. Sneh
1991 "New Horizons" Dr. S. Rosenblat
1994-1997 "New Horizons" Prof. Z. Naor
2000-2003 "New Horizons" Prof. Z. Naor
1994 Plant Physiology Prof. S. Beer
1995 Introduction to Botany A Prof. Y. Waisel
1996 Venomous Animals (Eilat) Prof. M. Spira (Hebrew University)
1998-2000 Light & colors in life of plants (M. Gurevitz, B. Epel, D. Chamovitz)
1998 Genetic engineering in biotechnology & medicine Dr. Ithay Benhar
1998 Biotechnology in industry Prof. D. Gutnick
1991-2008 Molecular Biology of Photosynthetic Prokaryotes Dr. M. Gurevitz
2002-2015 Plant Physiology Prof. M. Gurevitz
2002-2015 Plant Physiology Laboratory Prof. M. Gurevitz

 

ACTIVE PARTICIPATION IN SCIENTIFIC MEETINGS

42 conferences. Invited speaker in 30. Chairperson 6. Organizer 8.

 

ACADEMIC AND PROFESSIONAL RESPONSIBILITIES AND GRANTS

 -  BARD panel member in the Biotechnology section (1992, 1994).

 -  co-Organizer with Prof. I. Barash the "Plant Biotechnology" Internl. Conference held at Tel-Aviv University on May 17, 1993.

  -  Panel member of Chief Scientist of Agriculture, Biotechnology section (1994).

  -  Panel member, section of Plant Sciences, Israel Academy of Science (1995, 2000).

  -  Member in University Committee for graduate students (1997-2009).

  -  Member in Faculty Committee for Postdoc fellowships (1997-2008).

  -  Member in the Faculty Committee for Academic planning (1998-2000).

  -  Chairman of the Faculty Committee for Safety (1999, 2000).

  -  Member of Institute Steering Committee of Structural Biology (1998-2008).

  -  BARD panel member in the Biotechnology section (1999, 2000).

  -  Panel member of Chief Scientist of Agriculture, Biotechnology section (1999,2000).

  -  Head of University Safety Committee (2001-2015).

 

GRANTS RECEIVED AT TEL-AVIV UNIVERSITY

49 grants. Total amount of all above 60 million shekel.

 

MEMBERSHIP IN PROFESSIONAL SOCIETIES

Israel Tissue Culture and Plant Molecular Biology Society

International Society Plant Molecular Biology

International Society of Toxinology

 

STUDENTS SUPERVISED

Total number of graduated MSc students:                                                                 31

Total number of graduated PhD students:                                                                 16

Number of former Post Docs:                                                                                     6

Research Interests

Main Area of Research: 

 

(1) Interaction of toxin ligands with voltage-gated sodium channels. Main objectives:

  (i) Unravel the surface of interaction of these ligands with various channel subtypes (toxins bioactive surfaces and channel receptors);

   (ii) Identify molecular features underlying the varying preferences of ligands for different insect and mammalian channels;

   (iii) Design channel-selective ligands that would serve as leads for novel insecticides and medical drugs;

   (iv) Study the activation and inactivation of these channels and how various toxins affect these activities.

(2) Regulation of inorganic carbon aquisition in cyanobacteria. Main objectives: 

(i) To better undestand how Rubisco activity is regulated;

(ii) To develop a genetic system for manipulation and improvement of carbon aquisition;

(ii) To identify the rate limiting factors of carbon aquisition in the Calvin cycle of cyanobacteria.

Publications

  1. Zlotkin, E., Gurevitz, M. and Shulov, A. (1972) Toxic effects of tenebrionid beetles hemolymph on insects. Toxicon, 10: 537-542.
  2. Zlotkin, E., Gurevitz, M. and Shulov, A. (1972) Toxic effects of tenebrionid beetles' hemolymph on insects. In Animal and Plant Toxins (E. Keiser, ed.), pp. 135-142, W. Goldmann Verlag.
  3. Zlotkin, E., Gurevitz, M. and Shulov, A. (1973) The toxic effects of phenoloxidase from the hemolymph of tenebrionid beetles. J. Insect Physiol., 19:1057-1065.
  4. Gurevitz, M., Kratz, H. and Ohad, I. (1975) Chloroplastic origin of membrane proteins required for photosystem II activity in Euglena chloroplasts. Isr. J. Med. Sci. 11:1191-1192.
  5. Gurevitz, M., Kratz, H. and Ohad, I. (1977) Polypeptides of chloroplastic and cytoplastic origin required for development of photosystem II activity, and chlorophyll-protein complexes in Euglena gracilis Z chloroplast membranes. Biochim. Biophys. Acta, 461:475-488.
  6. Ohad, I., Bar-Nun, S., Cahen, D., Gershoni, J., Gurevitz, M., Kretzer, F., Shantz, R. and Sochat, S. (1977) Biogenesis of chloroplast membranes in algae. In Research in Photobiology, (A. Castellani, ed.) pp. 531-537.
  7. Cahen, D., Malkin, S., Gurevitz, M. and Ohad, I. (1978) Development of photosystem II apparatus in chloroplasts of Euglena gracilis Z during light-dark-light cycles. Plant Physiol., 62:1-5.
  8. Ohad, I., Bar-Nun, S., Cahen, D., Gershoni, J., Gurevitz, M., Lavintman, N. (1978) Stepwise synthesis and assembly of photosynthetic membranes in algae. In Photosynthesis 77, Proc. 4th Intern. Cong. Photosynthesis (D.O. Hall, J. Coombs and T.W. Goodwin, eds.), pp. 517-527, The Biochemical Society, London.
  9. Gurevitz, M., Watson, N. and Apirion, D. (1982) A cleavage site of ribonuclease F: A putative processing endoribonuclease from Escherichia coli. Eur. J. Biochem., 124:553-559.
  10. Jain, S., Gurevitz, M. and Apirion, D. (1982) A small RNA that complements mutants in the RNA processing enzyme Ribonuclease P. J. Mol. Biol., 162:515-533.
  11. Gurevitz, M., Jain, S. and Apirion, D. (1983) Identification of a precursor molecule for the RNA moiety of the processing enzyme Ribonuclease P. Proc. Natl. Acad. Sci. USA, 80:4450-4454.
  12. Gurevitz, M. and Apirion, D. (1983) Interplay among processing and degradative enzymes and precursor RNA molecules in the selective maturation and maintenance of RNA molecules. Biochemistry, 22:4000-4005.
  13. Gurevitz, M. and Apirion, D. (1983) Processing of bacteriophage T4 tRNAs: A precursor of species 1 RNA. FEBS Lett., 159:180-184.
  14. Watson, N., Gurevitz, M., Ford, J. and Apirion, D. (1984) Self cleavage of a precursor RNA from bacteriophage T4. J. Mol. Biol., 172:301-323.
  15. Gurevitz, M. and Apirion, D. (1985) The ribonuclease III-processing site near the 5' end of an RNA precursor of bacteriophage T4 and its effect on termination. Eur. J. Biochem., 147:581-586.
  16. McIntosh, L., Williams, J.G.K., Somerville, C.R. and Gurevitz, M. (1985) Genetic modification of photosynthesis. In Molecular form and function of the plant genome (van Vloten-Doting, L. G., S. P. Groot, T. C. Hall, eds.), pp. 335-346, Plenum Press.
  17. Somerville, C. R., McIntosh, L., Fitchen, J. and Gurevitz, M. (1985) The cloning and expression in E. coli of RuBP carboxylase/oxygenase large subunit genes. Methods in Enzymol., 118:419-433.
  18. Apirion, D., Dallmann, G., Gurevitz M., Miczak, A., Pragai, B., Subbarao, M.N., Szeberenyi, T. and Watson, N. (1985) Endonucleolytic Processing of RNA in a Prokaryotic Cell. In UCLA Symposia on Molecular and Cellular Biology New Series, Vol. 26, Nuclear Envelope Structure and RNA Maturation (Smuckler, E. A. and G. A. Clawson, eds.), pp. 331-354, A. R. Liss, Inc. New York, N.Y.
  19. Gurevitz, M., Somerville, C. R. and McIntosh, L. (1985) Pathway of assembly of ribulose bisphosphate carboxylase/oxygenase from Anabaena 7120 expressed in Escherichia coli. Proc. Natl. Acad. Sci. USA, 82:6546-6550.
  20. Jansson, C., Debus, R. J., Osiewacz, H. D., Gurevitz, M. and McIntosh, L. (1987) Construction of an obligate photoheterotrophic mutant of the cyanobacterium Synechocystis 6803. Plant Physiol., 85:1021-1025.
  21. Jansson, C., Debus, R. J., Osiewacz, H. D., Gurevitz, M. and McIntosh, L. (1987) Genetic modification of psbA genes in the cyanobacterium Synechocystis 6803. In Plant Gene Systems and their Biology (J. L. Key and L. McIntosh, eds.), Vol. 62, pp. 371-381, New York, A. R. Liss Inc.
  22. Gurevitz, M., Zlotkin, E. and Zilberberg, N. (1990) Characterization of the transcript for a depressant insect selective neurotoxin gene with an isolated cDNA clone from the scorpion Buthotus judaicus. FEBS Lett., 269:229-232.
  23. Zilberberg, N., Zlotkin, E. and Gurevitz, M. (1991) The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon, 29:1155-1158.
  24. Gurevitz, M., Osiewacz, H. D. and Keren, Y. (1991) Molecular evidence for interchromosomal recombination in the cyanobacterium Synechocystis sp. PCC6803. Plant Sci., 78:217-224.
  25. Cohen, Y. and Gurevitz, M. (1991) Ecology, Physiology and Molecular Genetics of Cyanobacteria. In The Prokaryotes (A. Balows, H. G. Trueper, M. Dworkin, W. Harder, and K. H. Schleifer, eds.), Vol. II, Chapter 98, pp. 2079-2104, Springer-Verlag, Second Edition.
  26. Gurevitz, M., Urbach, D., Zlotkin, E. and Zilberberg, N. (1991) Nucleotide sequence and structure analysis of a cDNA encoding an alpha insect toxin from the scorpion Leiurus quinquestriatus hebraeus. Toxicon, 29:1270-1272.
  27. Zilberberg, N., Zlotkin, E. and Gurevitz, M. (1992) Molecular analysis of cDNA and transcript encoding the depressant insect neurotoxin of the scorpion Leiurus quinquestriatus hebraeus. Insect Biochem. Molec. Biol., 22:199-203.
  28. Amichay, D., Sheffer, M. and Gurevitz, M. (1992) Restoration of the wild-type locus in an RuBP Carboxylase/Oxygenase mutant of Synechocystis PCC6803 via targeted gene recombination. Molec. Gen. Genet., 235:247-252.
  29. Zlotkin, E., Gurevitz, M., Fowler, E., Moyer, M. and Adams, M. E. (1993) Depressant insect selective neurotoxins from scorpion venom: chemistry, action and gene cloning. Arch. Insect Biochem. Physiol., 22:55-73.
  30. Amichay, D., Levitz, R. and Gurevitz, M. (1993) Construction of a Synechocystis PCC6803 mutant suitable for the study of a variant hexadecameric RuBP Carboxylase/Oxygenase enzymes. Plant Mol. Biol., 23:465-476.
  31. Zilberberg, N. and Gurevitz, M. (1993) Rapid isolation of full length cDNA clones by "inverse PCR": Purification of a scorpion cDNA family encoding a-neurotoxins. Anal. Biochem., 209:203-205.
  32. Cohen-Kupiec, R., Gurevitz, M., and Zilberstein, A. (1993) Expression of glnA in the cyanobacterium Synechococcus strain PCC7942 is initiated from a single nif-like promoter, under various nitrogen conditions. J. Bacteriol., 175:7727-7731.
  33. Ogawa, T., Amichay, D. and Gurevitz, M. (1994) Isolation and characterization of the ccmM gene required by the cyanobacterium Synechocystis PCC6803 for inorganic carbon utilization. Photosynth. Res., 39:183-190.
  34. Gurevitz, M. and Zilberberg, N. (1994) Advances in molecular genetics of scorpion neurotoxins. J. Toxicol. Toxin Rev., 13:65-100.
  35. Zlotkin, E., Eitan, M., Pelhate, M., Chejanovsky, N., Gurevitz, M. and Gordon, D. (1994) Insect specific neurotoxins from scorpion venom that affect sodium current inactivation. J. Toxicol. Toxin Rev., 13:25-43.
  36. Cohen-Kupiec, R., Zilberstein, A. and Gurevitz, M. (1995) Characterization of cis elements that regulate the expression of glnA in Synechococcus sp. strain PCC7942. J. Bacteriol., 177:2222-2226.
  37. Gurevitz, M., Zilberberg, N., Urbach, D., Gordon, D., Zlotkin, E. and Chejanovsky, N. (1995) Alpha scorpion neurotoxins and baculoviruses: A working model for the design of Novel selective insecticides. Bielefeld, Germany, In Bielefelder Okologische Beitrage, 8:25-41.
  38. Chejanovsky, N., Zilberberg, N., Rivkin, H., Zlotkin, E. and Gurevitz, M. (1995) Functional expression in insect cells and in lepidopterous larvae of a scorpion anti-insect alpha neurotoxin. FEBS Lett., 376:181-184.
  39. Zilberberg, N., Gordon, D., Zlotkin, E., Pelhate, M. Adams, M.E., Norris, T. and Gurevitz, M. (1996) Functional expression and genetic modification of an alpha scorpion neurotoxin. Biochemistry, 35:10215-10222.
  40. Gurevitz, M., Zilberberg, N., Froy, O., Urbach, D., Zlotkin, E., Hammock, B. D.,Herrmann, R., Moskowitz, H. and Chejanovsky, N. (1996) Utilisation of scorpion insecticidal neurotoxins and baculoviruses for the design of novel selective biopesticides. In Modern Agriculture and the Environment (D. Rosen and E. Tel-Or, eds.), pp. 81-96, KluwerAcademic Publ.
  41. Zilberberg, N., Froy, O., Cestele, S., Loret, E., Arad, D., Gordon, D. and Gurevitz, M. (1997) Identification of structural elements of a scorpion alpha neurotoxin important for receptor-site recognition. J. Biol. Chem., 272:14810-14816.
  42. Tugarinov, V., Kustanovitz, I., Zilberberg, N., Gurevitz, M. and Anglister, Y. (1997) Solution structures of a highly insecticidal recombinant scorpion a-toxin and a mutant with increased activity. Biochemistry, 36:2414-2424.
  43. Turkov, M., Rashi, S., Zilberberg, N., Gordon, D., BenKhalifa, R., Stankiewicz, M., Pelhate, M. and Gurevitz, M. (1997) Expression in Escherichia coli and reconstitution of a functional recombinant depressant scorpion neurotoxin specific against insects. Prot. Exp. Purific., 10:123-131.
  44. Benkhalifa, R., Stankiewicz, M., Lapied, B., Turkov, M., Zilberberg, N., Gurevitz, M. and Pelhate, M. (1997) Refined electrophysiological analysis suggests that scorpion depressant neurotoxins are sodium channel openers rather than blockers. Life Sci., 61:819-830.
  45. Gershburg, E., Stockholm, D., Froy, O., Rashi, S., Gurevitz, M. and Chejanovsky, N. (1998) Baculovirus-mediated expression of a scorpion depressant toxin improves significantly the insecticidal efficacy achieved with excitatory toxins. FEBS Lett., 422:132-136.
  46. Gurevitz, M., Froy, O., Zilberberg, N., Turkov, M., Strugatsky, D., Gershburg, E., Lee, D., Adams, M. E., Tugarinov, V., Anglister, J., Shaanan, B., Loret, E., Stankiewicz, M., Pelhate, M., Gordon, D. and Chejanovsky, N. (1998) Sodium channel modifiers from Scorpion venom: Structure-activity relationship, mode of action, and application. Toxicon, 6:1671-1682.
  47. Gordon, D., Savarin, P., Gurevitz, M. and Zinn-Justin, S. (1998) Functional anatomy of scorpion toxins affecting sodium channels. J. Toxicol. Toxin Rev., 17:131-158.
  48. Oren, D., Froy, O., Amit, E., Kleinberger-Doron, N., Gurevitz, M. and Shaanan, B. (1998) An excitatory scorpion toxin with a distinctive feature: an additional a-helix at the C-terminus and its implications for interaction with insect sodium channels. Structure, 6:1095-1103.
  49. Froy, O. and Gurevitz, M. (1998) Membrane potential modulators: a thread of scarlet from plants to humans. FASEB J., 12:1793-1796.
  50. Froy, O., Sagiv, T., Poreh, M., Urbach, D., Zilberberg, N. and Gurevitz, M. (1999) Dynamic diversification from a putative common progenitor of scorpion toxins affecting sodium, potassium and chloride channels. J. Mol. Evol., 48:187-196.
  51. Gurevitz, M., Froy, O., Zilberberg, N., Shaanan, B., Adams, M. E., Anglister, J., Pelhate, M., Chejanovsky, N. and Gordon, D. (1999) Elucidation of the active site and potential applications of sodium channel modifiers from scorpion venom. In Progress in Neuropharmacology and Neurotoxicology of Pesticides and Drugs (D. J. Beadle, ed.), pp. 67-80, Oxford, UK.
  52. Froy, O., Zilberberg, N., Gordon, D., Turkov, M., Gilles, N., Stankiewicz, M., Pelhate, M., Loret, E., Oren, D., Shaanan, B. and Gurevitz, M. (1999) The putative bioactive surface of insect-selective scorpion excitatory neurotoxins. J. Biol. Chem., 274:5769-5776.
  53. Froy, O., Zilberberg, N., Chejanovsky, N., Anglister, J., Loret, E., Shaanan, B., Gordon, D. and Gurevitz, M. (2000) Scorpion neurotoxins: Structure/function relationships and application in agriculture. Pest. Manag. Sci., 56:472-474.
  54. Lee, D., Gurevitz, M. and Adams, M. E. (2000) Modification of synaptic transmission and sodium channel inactivation by the insect-selective scorpion toxin LqhaIT. J. Neurophysiol., 83:1181-1187.
  55. Marcus, Y. and Gurevitz, M. (2000) Activation of cyanobacterial RuBP-carboxylase/ oxygenase is facilitated by inorganic phosphate via two distinct mechanisms. Eur. J. Biochem., 267:5995-6003.
  56. Gilles, N., Krimm, I., Bouet, F., Froy, O., Gurevitz, M., Lancelin, J-M. and Gordon, D. (2000) Structural implications on the interaction of scorpion a-like toxins with the sodium channel receptor site inferred from toxin iodination and pH-dependent binding. J. Neurochem., 75:1735-1745.
  57. Gurevitz, M., Gordon, D., Ben-Natan, S., Turkov, M. and Froy, O. (2001) Diversification of neurotoxins by C-tail ‘wiggling’ - a scorpion recipe for survival. FASEB J., 15:1201-1205.
  58. Gilles, N., Harrison, G., Karbat, I., Gurevitz, M., Nicholson, G. M. and Gordon, D. (2002) Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider d-Atracotoxin. Eur. J. Biochem., 269:1500-1510.
  59. Gordon, D., Gilles, N., Bertrand, D., Molgo, J., Nicholson, G. N., Sauviat, M. P., Shichor, I., Lotan, I., Gurevitz, M., Kallen, R. G. and Heinemann, S. H. (2002) Scorpion toxins differentiating among neuronal sodium channel subtypes: Nature’s guide for design of selective drugs. In Perspectives in Molecular Toxinology (Menez, A., ed.), pp. 215-238, Wiley and Sons, Chichester, UK.
  60. Gurevitz, M., Zilberberg, N., Froy, O., Turkov, M., Vilunsky, R., Karbat, I., Anglister, J., Shaanan, B., Pelhate, M., Adams, M. E., Gilles, N., and Gordon, D. (2002) Diversification of toxic sites on a conserved protein scaffold: a scorpion recipe for survival. In Perspectives in Molecular Toxinology (Menez, A., ed.), pp. 239-253, Wiley and Sons, Chichester, UK.
  61. Gordon, D. and Gurevitz, M. (2003) The selectivity of scorpion a-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface. Toxicon, 41:125-128.
  62. Marcus, Y., Altman-Gueta, H., Finkler, A. and Gurevitz, M. (2003) The dual role of cysteine172 in redox regulation of Rubisco activity and degradation. J. Bacteriol., 185:1509-1517.
  63. Regev, A., Rivkin, H., Inceoglu, B., Gershburg, E., Hammock, B. D., Gurevitz, M. and Chejanovsky, N. (2003) Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively. FEBS Lett., 537:106-110.
  64. Gilles, N., Gurevitz, M. and Gordon, D. (2003) Allosteric interactions among pyrethroid, brevetoxin, and scorpion toxin receptors on insect sodium channels raise an alternative approach for insect control. FEBS Lett., 540:81-85.
  65. Gordon, D., Zilberberg, N., Ilan, N., Gilles, N., Urbach, D., Cohen, L., Karbat, I., Froy, O., Gaathon, A., Kallen, R. G., Benveniste, M. and Gurevitz, M. (2003) An ‘Old World’ scorpion b-toxin that recognizes both insect and mammalian sodium channels: a possible link towards diversification of b-toxins. Eur. J. Biochem., 270:2663-2670.
  66. Froy, O. and Gurevitz, M. (2003) New insight on scorpion divergence inferred from comparative analysis of toxin structure, pharmacology and distribution. Toxicon, 42:549-555.
  67. Froy, O. and Gurevitz, M. (2003) Arthropod and Mollusk defensins - evolution by exon shuffling. Trends Genet., 19:684-687.
  68. Cohen, L., Karbat, I., Gilles, N., Froy, O., Corzo, G., Angelovici, R., Gordon, D. and Gurevitz, M. (2004) Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative ‘hot spot’ common to all scorpion b-toxins affecting Na+ channels. J. Biol. Chem., 279:8206-8211.
  69. Karbat, I., Cohen, L., Gilles, N., Gordon, D. and Gurevitz, M. (2004) Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels. FASEB J., 18:683-689.
  70. Froy, O. and Gurevitz, M. (2004) Arthropod defensins illuminate the divergence of scorpion neurotoxins. J. Pept. Sci., 10:714-718.
  71. Karbat, I., Frolow, F., Froy, O., Gilles, N., Cohen, L., Turkov, M., Gordon, D. and Gurevitz, M. (2004) Molecular basis of the high insecticidal potency of scorpion a-toxins. J. Biol. Chem., 279:31679-31686.
  72. Tan, J., Liu, Z., Wang, R., Huang, Z., Chen, A. C., Gurevitz, M. and Dong, K. (2005) Identification of amino acid residues critical for pyrethroid binding to insect sodium channels. Mol. Pharmacol., 67:513-522.
  73. Corzo, G., Escoubas, E., Villegas, E., Karbat, I., Gordon, D., Gurevitz, M., Nakajima, T. and Gilles, N. (2005) A spider toxin that induces a typical effect of scorpion a-toxins but competes with b-toxins on binding to insect sodium channels. Biochemistry, 44:1542-1549.
  74. Cohen, L., Karbat, I., Gilles, N., Ilan, N., Gordon, D. and Gurevitz, M. (2005) Common features in the functional surface of scorpion b-toxins and elements that confer specificity for insect and mammalian voltage-gated Na-channels. J. Biol. Chem., 280:5045-5053.
  75. Marcus, Y., Altman-Gueta, H., Finkler, A. and Gurevitz, M. (2005) Mutagenesis at two distinct phosphate-binding sites unravels their differential role in regulation of Rubisco activation and catalysis. J. Bacteriol., 187:4222-4228.
  76. Strugatsky, D., Zilberberg, N., Ilan, N., Turkov, M., Cohen, L., Stankiewicz, M., Pelhate, M., Gilles, N., Gordon, D. and Gurevitz, M. (2005) Expression of a gene family encoding a novel scorpion depressant toxin illuminates the key role of asparagine-58 in activity on insect neuronal sodium channels. Biochemistry, 44:9179-9187.
  77. Cohen, L., Gilles, N., Karbat, I., Ilan, N., Gordon, D. and Gurevitz, M. (2006) Direct evidence that receptor site-4 of sodium channel gating modifiers is not dipped in the phospholipid bilayer of neuronal membranes. J. Biol. Chem., 281:20673-20679.
  78. Moran, Y., Cohen, L., Kahn, R., Karbat, I., Gordon, D. and Gurevitz, M. (2006) Expression and mutagenesis of the sea anemone toxin Av2 reveals key amino acid residues important for activity on insect voltage-gated sodium channels. Biochemistry, 45:8864-8873.
  79. Moran, Y. and Gurevitz, M. (2006) When positive selection of neurotoxin genes is missing - the riddle of the sea anemone Nematostella vectensis. FEBS J., 276:3886-3892.
  80. Regev, A., Rivkin, H., Gurevitz, M. and Chejanovsky, N. (2006) New measures of insecticidal efficacy and safety obtained with the 39K promoter of a recombinant baculovirus. FEBS Lett., 580:6777-6782.
  81. Snir, A., Gurevitz, M. and Marcus, Y. (2006) Photosynthetic diurnal rhythm in aerial leaves of the amphibious-plant Nuphar lutea is induced by alterations in Rubisco activity and stomatal behavior. Photosynthesis Res., 90:233-242.
  82. Karbat, I., Turkov, M., Cohen, L., Kahn, R., Gordon, D., Gurevitz, M. and Frolow, F. (2007) X-ray structure and mutagenesis of the scorpion depressant toxin LqhIT2 reveals key determinants crucial for activity and anti-insect selectivity. J. Mol. Biol.­, 366:586-601.
  83. Gurevitz, M., Karbat, I., Cohen, L., Ilan, N., Kahn, R., Turkov, M., Stankiewicz, M., Stühmer, W., Dong, K. and Gordon, D. (2007) The insecticidal potential of scorpion beta-toxins. Toxicon, 49:473-489.
  84. Gordon, D., Karbat, I., Ilan, N., Cohen, L., Kahn, R., Gilles, N., Dong, K., Stühmer, W., Tytgat, J. and Gurevitz, M. (2007) The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control. Toxicon, 49:452-472.
  85. Karbat, I., Kahn, R., Cohen, L., Ilan, N., Gilles, N., Corzo, G., Froy, O., Gur, M., Albrecht, G., Heinemann, S.H., Gordon, D. and Gurevitz, M. (2007) The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail. FEBS J., 274:1918-1931.
  86. Moran, Y., Kahn, R., Cohen, L., Gur, M., Karbat, I., Gordon, D. and Gurevitz, M. (2007) Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na-channels. Biochem. J., 406:41-48.
  87. Cohen, L., Ilan, N., Gur, M., Stühmer, W., Gordon, D. and Gurevitz, M. (2007) Design of a specific activator for skeletal muscle voltage-gated sodium channels uncovers channel architecture. J. Biol. Chem., 282:29424-29430.
  88. Cohen, L., Troub, Y., Turkov, M., Gilles, N., Ilan, N., Benveniste, M., Gordon, D. and Gurevitz, M. (2007) Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant 'insect-selective' toxins when preconditioned. Mol. Pharmacol., 72:1220-1227.
  89. Schnur, E., Turkov, M., Kahn, R., Gordon, D., Gurevitz, M. and Anglister, J. (2008) NMR analysis of interaction of LqhaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect Para voltage-gated sodium channel. Biochemistry, 47:911-921.
  90. Moran, Y., Weinberger, H., Sullivan, J.C., Reitzel, A.M., Finnerty, J.R. and Gurevitz, M. (2008) 'Concerted Evolution' of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome. Mol. Biol. Evol., 25:737-747.
  91. Cohen, L., Lipstein, N., Karbat, I., Ilan, N., Gilles, N., Kahn, R., Gordon, D. and Gurevitz, M. (2008) Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated Na-channels. J. Biol. Chem., 283:15169-15176 (paper of the week).
  92. Moran, Y., Weinberger, H., Reitzel, A.M., Sullivan, J.C., Kahn, R., Gordon, D., Finnerty, J.R. and Gurevitz, M. (2008) Intron retention as a post-transcriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis. J. Mol. Biol., 380:437-443.
  93. Marcus, Y., Altman-Gueta, H., Snir, A., Wolff, Y. and Gurevitz, M. (2008) Does Rubisco limit the rate of photosynthesis? in 'Photosynthesis, Energy From The Sun (Allen, J.F., Gantt, E., Golbeck, J.H. and Osmond, B., eds.) 14th International Congress on Photosynthesis, pp. 867-871, Springer Verlag.
  94. Moran, Y., Weinberger, H., Lazarus, N., Gur, M., Kahn, R., Gordon, D. and Gurevitz, M. (2009) Fusion and retrotransposition events in the evolution of sea anemone neurotoxin genes. J. Mol. Evol., 69:115-124.
  95. Cohen, L., Moran, Y., Sharon, A., Segal, D., Gordon, D. and Gurevitz, M. (2009) Drosomycin, an innate immunity peptide of Drosophila, interacts with DmNav1 of the nervous system. J. Biol. Chem., 284:23558-23563.
  96. Kahn, R., Karbat, I., Ilan, N., Cohen, L., Gordon, D. and Gurevitz, M. (2009) Molecular requirements for specific recognition of brain voltage-gated sodium channels by scorpion alpha-toxins. J. Biol. Chem., 284:20684-20691.
  97. Moran, Y., Gordon, D. and Gurevitz, M. (2009) Sea anemone toxins affecting voltage-gated sodium channels - molecular and evolutionary features. Toxicon, 54:1089-1101.
  98. Weinberger, H., Moran, Y., Kahn, R., Gordon, D. and Gurevitz, M. (2010) Positions under positive selection - key for selectivity and potency of scorpion a-toxins. Mol. Biol. Evol., 27:1025-1034.
  99. Paldi, T. and Gurevitz, M. (2010) Coupling between residues on S4 and S1 define the voltage sensor resting conformation in NaChBac. Biophys. J., 99:456-463.
  100. Karbat, I., Ilan, N., Zhang, J.Z., Cohen, L., Kahn, R., Benveniste, M., Scheuer, T., Catterall, W.A., Gordon, D. and Gurevitz, M. (2010) Partial agonist and antagonist activities of a mutant scorpion b-toxin on sodium channels. J. Biol. Chem., 285:30531-30538.
  101. Song, W., Du, Y., Liu, Z., Luo, N., Turkov, M., Gordon, D., Gurevitz, M., Goldin, A.L. and Dong, K. (2011) Mutations in the voltage sensor in domain III enhance the sensitivity of an insect sodium channel to a scorpion b-toxin. J. Biol. Chem., 286:15781-15788.
  102. Marcus, Y., Altman-Gueta, H., Wolff, Y. and Gurevitz, M. (2011) Mutagenesis at Rubisco active site impairs catalysis but hardly affects photosynthesis and growth of the cyanobacterium Synechocystis PCC6803. J. Exp. Bot., 62:4173-4182.
  103. Zhang, J.Z., Karbat, I., Cohen, L., Yarov-Yarovoy, V., Scheuer, T., Gordon, D., Gurevitz, M. and Catterall, W.A. (2011) Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels. J. Biol. Chem., 286:33641-33651.
  104. Wang, J., Yarov-Yarovoy, V., Kahn, R., Gordon, D., Gurevitz, M., Scheuer T. and Catterall W.A. (2011) Mapping the receptor site for a-scorpion toxins on a sodium channel voltage sensor. Proc. Natl. Acad. Sci. USA, 108:15426-15431.
  105. Gur, M., Kahn, R., Regev, N., Wang, J., Catterall, W.A., Gordon, D. and Gurevitz, M. (2011) Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core-domain of scorpion alpha-toxins on sodium channels. J. Biol. Chem., 286:35209-35217.
  106. Moran, Y., Genikhovich, G., Gordon, D., Technau, U. and Gurevitz, M. (2012) Localization of neurotoxins to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones. Proc. Royal Soc. B., 279:1351-1358.
  107. Gurevitz, M. (2012) Mapping the scorpion toxin receptor sites at voltage-gated sodium channels. Toxicon, 60:502-511.
  108. Gur Barzilai, M, Reitzel, A.M., Eitel, M., Schierwater, B., Genikhovich, G., Technau, U., Gordon, D., Gurevitz, M., and Moran, Y. (2012) Convergent evolution of sodium selectivity in metazoan voltage-gated ion channels. Cell Rep., 2:242-248.
  109. Zhang, J.Z, Yarov-Yarovoy, V., Scheuer, T., Karbat, I., Cohen, L., Gordon, D., Gurevitz, M. and Catterall, W.A. (2012) Mapping the interaction site for a b-scorpion toxin in the pore module of domain III of voltage-gated sodium channels. J. Biol. Chem., 287:30719-30728.
  110. Ma, Z., Kong, J., Gordon, D., Gurevitz, M. and Kallen, R.G. (2013) Direct evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movements. PLoS One, 8(11):e77758.
  111. Gao, R., Du, Y., Wang, L., Nomura, Y., Satar, G., Gordon, D., Gurevitz, M., Goldin, A.L. and Dong, K. (2014) Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. Neuroscience, 268:297-308.
  112. Gur Barzilai, M., Kahn, R., Regev, N., Gordon, D., Moran, Y. and Gurevitz, M. (2014) The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore region of target sodium channels. Biochem. J., 463:271-277.
  113. Gurevitz, M. (2014) An international high court for scientific debates is now required. Commentary to "Science ethics: young scientists speak". Science 345:24-27.
  114. Gurevitz, M., Gordon, D., Gur Barzilai, M., Kahn, R., Cohen, L., Moran, Y., Zilberberg, N., Froy, O., Altman-Gueta, H., Turkov, M., Dong, K. and Karbat, I. (2015) Molecular description of scorpion toxin interaction with voltage-gated sodium channels. In: Toxinology: Scorpion Toxins (Gopalakrishnakone, P., Ferroni Schwartz, E., Possani, L.D., Rodríguez de la Vega, R.C., Eds.) Springer.
  115. Marcus, Y. and Gurevitz, M. (2016) Ornidazole and related compounds to use as herbicides. US Patent US9237750B2 assigned to Ramot, Tel Aviv University.
  116. Gurevitz, M. and Altman Gueta Hagit (2016) The paradox of scorpion toxin interactions with portable Nav receptors. JSM Chemistry, 4(2):1023 (open access).
  117. Marcus, Y., Tal, N., Ronen, M., Carmieli, R. and Gurevitz, M. (2016) The drug ornidazole inhibits photosynthesis in a different mechanism described for protozoa and anaerobic bacteria. Biochem. J., 473:4413-4426.
  118. Marcus, Y., Tal, N., Ronen, M., Carmieli, R. and Gurevitz, M. (2017) The drug ornidazole inhibits photosynthesis in a different mechanism described for protozoa and anaerobic bacteria. Biochem. J., 474:4269.
  119. Karbat, I., Altman-Gueta H., Fine, S., Szanto, T., Hamer-Rogotner, S., Dym, O., Frolow, F., Gordon, D., Panyi, G., Gurevitz, M. and Reuveny, R. (2019) Pore-modulating toxins exploit inherent slow inactivation to block K+ channels. Proc. Natl. Acad. Sci. USA, 116:18700-18709.
  120. Marcus, Y. and Gurevitz, M. (2020) Ferredoxin-mediated reduction of 2-nitrothiophene inhibits photosynthesis: Mechanism and herbicidal potential. Biochem. J., 477, 1149-1158.
  121. Gurevitz, M. (2020) The myth of the Corona monster. J. Pharmacol. Pharmaceut. Res., In press.
  122. Gurevitz, M. (2020) The puzzle of scorpion toxins binding to voltage-gated sodium channels. World J. Biol. Chem., In press.
Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
UI/UX Basch_Interactive