Dr. Nechama Smorodinsky

היברידומות בדימוס
Dr. Nechama Smorodinsky
Phone: 03-6409115
Fax: 03-6422046
Office: Britannia-Porter, 304

Research Interests

My research interests are:

  • Human Breast Cancer – isoforms of MUC-1 in human breast cancer for diagnosis, prognosis and treatment
  • Vaccination against human breast cancer
  • Interactions between MUC-1 expressing tumor cells and the microenvironmental factors such as immunocytes and chemokines
  • Developing MUC-1 monoclonal antibodies for breast cancer treatment
  • Monoclonal antibodies for the study of ATM structure/function relationship

 

Recent Publications

Levitin F, Baruch A, Weiss M, Stiegman K, Hartmann ML, Yoeli-Lerner M, Ziv R, Zrihan-Licht S, Shina S, Gat A, Lifschitz B, Simha M, Stadler Y, Cholostoy A, Gil B, Greaves D, Keydar I, Zaretsky J, Smorodinsky N, Wreschner DH. A novel protein derived from the MUC1 gene by alternative splicing and frameshifting. J Biol Chem. Vol. 280, 2005 (pp. 10655-10663).

 

Zipin A, Israeli-Amit M, Meshel T, Sagi-Assif O, Yron I, Lifshitz V, Bacharach E, Smorodinsky NI, Many A, Czernilofsky PA, Morton DL, Witz IP. Tumor-microenvironment interactions: the fucose-generating FX enzyme controls adhesive properties of colorectal cancer cells. Cancer Res. Vol. 64, 2004 (pp. 6571-6578).
 

Herbert LM, Grosso JF, Dorsey M Jr, Fu T, Keydar I, Cejas MA, Wreschner DH, Smorodinski N, Lopez DM. A unique mucin immunoenhancing peptide with antitumor properties. Cancer Res. Vol. 64, 2004 (pp. 8077-8084).

 

N.A. Hey, M. Meseguer, C. Simon, N.I. Smorodinsky, D.H. Wreschner, M.E. Ortíz, J.D. Aplin. Transmembrane and truncated (SEC) isoforms of MUC1 in the human endometrium and Fallopian tube. Reprod. Biol. Endocrinol. Vol. 1, 2003 (p. 2).
 

A.S. Solomon, M. Kimron, V. Holdengreber, A. Nizan, M. Yaakobowicz, E. Harness, N.I. Smorodinsky, A. Shirvan , A. Barzilai. Up-regulation of semaphorin expression in retina of glaucomatous rabbits. Graefes Arch Clin Exp Ophthalmol. Vol. 241, 2003 (pp. 673-681).

 

D.H. Wreschner, M.A. McGuckin, S.J. Williams, M. Yoeli, R. Ziv, L. Okun, J. Zaretsky, N.I. Smorodinsky, I. Keydar, M. Stacey, H-H. Lin, S. Gordon. Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein Sci. Vol. 11, 2002 (pp.698-706).

 

A. Bar-Shira, S. Rashi-Elkeles, L. Zlochover, N.I. Smorodinsky, R. Seger, Y. Shiloh. ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage. Oncogene. Vol. 21, 2002 (pp.849-855).

 

S. Vahdati-Ben Arieh, B. Zimmerman, N.I. Smorodinsky, M. Yaakubovicz, C. Schechter, I. Bacik, J. Gibbs, J.R. Bennink, J.W. Jewdell, J.E. Coligan, H. Firat, F. Lemonnier, R. Ehrlich. Human cytomegalovirus protein US2 interferes with the expression of human HFE, a non classical class I major histocompatibility complex molecule that regulates iron homeostasis. J. Virol. Vol. 75, 2001 (pp.10557-10562).

 

E. Seroussi, N. Shani, D. Ben-Meir, A. Chajut, I. Divinski, S. Faier, S. Gery, S. Karby, Z. Kariv-Inbal, O. Sella, N.I. Smorodinsky, S. Lavi S. Uniquely conserved non-translated regions are involved in generation of the two major transcripts of Protein Phosphatase 2C. J Mol Biol. Vol. 312; 2001 (pp.439-451).

 

B. Lifschitz-Mercer, Y. Sheinin, D. Ben-Meir, L. Bramante-Schreiber, L. Leider-Trejo, S. Karby, N.I. Smorodinsky, S. Lavi. Protein phosphatase 2C expression in normal human tissues: an immunohistochemical study. Histochem Cell Biol. Vol.116, 2001 (pp.31-39).

 

V.M. Macaulay, Salisbury AJ, Bohula EA, Playford MP, Smorodinsky NI, Shiloh Y. Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene Vol.20, 2001 (pp.4029-4040).

 

Spring, K., S. Cross, C. Li, L. Ben-Senior, D. Watters, P. Waring, F. Ahangari, P. Chen, I. Misko, C. Paterson, G. Kay, N.I. Smorodinsky, Y. Shiloh, M.F. Lavin. Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype. Cancer Res. Vol.61, 2001 (pp.4561-4568).

 

Eshel, R., A. Zanin, O. Sagi-Assif, T. Meshel, N.I. Smorodinsky, O. Dwir, R. Alon, R. Brakenhoff, G. van Dongen, I.P. Witz. The GPI-linked Ly-6 antigen E48 regulates expression levels of the FX-enzyme and of E-selectin ligands on Head and Neck Squamous Carcinoma Cells. J. Biol. Chem., Vol. 275, 2000 (pp.12833-12840).

 

Baruch, A., M. Hartman, M. Yoeli, Y. Adereth, S. Greenstein, Y. Stadler, Y. Skornik, J. Zaretsky, N.I. Smorodinsky, I. Keydar, D.H. Wreschner. The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein.Cancer Res. Vol.59, 1999 (pp. 1552-1561).

 

Hartman, M., A. Baruch, I. Ron, H. Gil, Y. Adereth, S. Greenstein, S. Yaakubovits, E. Harnes, S. Shina, I. Keydar, N.I. Smorodinsky, D.H. Wreschner. The MUC1 isoform specific monoclonal antibodies, 6E6/2, detect preferential expression of the mouse MUC1/Y like protein in breast cancer and other epithelial malignancies. Int. J. Cancer, Vol. 82, 1999 (pp.254-266).

 

Banin, S., L. Moyal, S.-Y. Shieh, Y. Taya, C.W. Anderson, L. Chessa, N.I. Smorodinsky, C. Prives, Y. Reiss, Y. Shiloh, Y..Ziv. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science Vol.281, 1998 (pp.1674-1677).

 

Treister, A., O. Sagi-Assif, M. Meer, N.I. Smorodinsky, R. Anavi, I. Golan, T. Meshel, O. Kahana, R. Eshel, B-Z. Katz, E. Shevach, I.P. Witz. Expression of Ly-6, a marker for highly malignant murine tumor cells, is regulated by growth conditions and stress. Int. J. Cancer Vol.77, 1998 (pp.306-313).

 

Baruch, A., M. Hartman, S. Zrihan-Licht, M. Burstein, I. Keydar, M. Weiss, N.I. Smorodinsky, D.H. Wreschner. Preferential expression of novel MUC1 tumor antigen isoforms in human epithelial tumors and their tumor potentiating function. Int. J. Cancer, Vol.71, 1997 (pp.741-749).

 

Williamson, A.R., D. Peretz, N.I. Smorodinsky, R. Bastidas, H. Serban, I. Melhorn, S. DeArmond, S.B. Prusiner, D.R. Burton. Circumventing Tolerance to generate autologous monoclonal antibodies to the Prion protein. Proc. Natl. Acad. Sci. USA, Vol. 93, 1996 (pp.7279-7282).

 

Denisova, G., B. Stern, D. Raviv, J. Zwickel, N.I. Smorodinsky, J.M. Gershoni. Humoral Immune Response to Immuno-complexed HIV Envelope protein gp120. AIDS Res. & Hum. Retro., Vol. 12, 1996 (pp.901-909).

 
 
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