Prof. Reuven Stein

מחלקה לנוירוביולוגיה סגל אקדמי בכיר
Prof. Reuven Stein
Phone: 03-6408608
Fax: 03-6407643
Office: Sherman - Life Sciences, 724

Research Interests

The research in our laboratory focuses on three main topics:

1. Regulated cell death processes; focusing on apoptosis and Bcl-2 family proteins.

2. Regulation of tumor microenvironment by the multifunctional protein CD38; therapeutic implications

2. Regulation of brain tumors by microglia and bone marrow derived macrophages 

 

For a more detailed research description 

 

Recent Publications

 

Mayo L, Jacob-Hirsch J, Amariglio N, Rechavi G, Moutin MJ Lund FE and Stein R. (2008) Dual role of CD38 in microglial activation and activation induced cell death. J. Immunol. 81:92-103.

 

Levy A, Bercovich-Kinori A, Alexandrovich AG, Tsente J, Trembovler V,, Lund FE, Shohami E, Stein R, and Lior Mayo. (2009) CD38 Facilitates Recovery from Traumatic Brain Injury.  J. Neurotrauma. 26:1521-1533.

 

Starinsky-Elbaz S, Faigenbloom L, Friedman E, Stein R and Kloog Y. (2009) The Pre-GAP-related Domain of Neurofibromin Regulates Cell Migration through the LIM Kinase/Cofilin Pathway  Mol. Cell Neurosci. 42:278-287.

 

Lindenboim L, Blacher E, Borner B, and Stein R. (2010) Regulation of stress-induced nuclear proteins' redistribution: a novel function of Bax and Bak uncoupled from Bcl-xL. Cell Death Differ. 17:346-59.

 

Robinson A, Kloog Y, Stein R and Assaf Y (2010). Motor deficits and neurofibromatosis type 1 (NF1)-associated MRI impairments in a mouse model of NF1. NMR in Biomedicine, 23:1173-1180.

 

Farfara, D., Trudler, D Segev-Amzaleg, N., Galron, R., Stein, R, and Frenkel, D (2010). g-secretase component presenilin is important for microglia b-Amyloid clearance. Ann Neurol.  69(1):170-80.

 

Mayo L, Levy L, Jacob-Hirsch J, Amariglio N, Rechavi G and Stein R. (2011) Bid regulates the immunological profile of microglia and macrophages. Glia 59:397-412.

 

Lindenboim L, Borner, C, and Stein R. Nuclear proteins acting on mitochondria (2011). Biochim. Biophys. Acta. 1813:584-96.

 

Levy A, Blacher E, Vaknine H, Lund FE, Stein R*, and Mayo L. (2012) CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages. Neuro-Oncol 14:1037-1049.

 

Lindenboim L, Ferrando-May E, Borner C and Stein, R. (2013) Non-canonical function of Bax in stress-induced nuclear protein redistribution. Cell Mol Life Sci. 70:3013-3027.

 

Robinson A, Grimm OM, Grösgen S, Müller UC, Hartmann T and Stein R. (2014) Presenilin 1 regulates expression of the transcriptional coactivator PGC-1α via the intracellular domain of amyloid precursor protein (APP): implications for mitochondrial energy metabolism. Aging Cell 13:263-272.

 

Lindenboim L, Sasson T, Worman HJ, Borner C, Stein R. (2014) Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release. Nucleus. 5:527-541.

 

Blacher E, Ben Baruch B, Levy A, Geva N, Green KD, Garneau-Tsodikova S, Fridman M, and Stein R. (2015) Inhibition of glioma progression by a newly discovered CD38 inhibitor. Int. J. Cancer. 136:1422-1433.

 

Blacher E, Levy L, Ben-Baruch B, Green KD, Garneau-Tsodikova S, Fridman F, and Stein R. (2015). Targeting CD38 in the tumor microenvironment; a novel approach to treat glioma. Cancer Cell & Microenvironment. 2: e486. doi: 10.14800/ccm.486.

 

Blacher E, Dadali T, Bespalko A, Haupenthal VJ, Grimm MO, Hartmann T, Lund FE, Stein R*, Levy A. (2015) Alzheimer’s disease pathology is attenuated in a CD38 deficient mouse model. Ann Neurol. 78:88-103.

 

Shaul P, Steinbuch K, Blacher B, Stein R* and Fridman F*. (2015) Exploring the Effects of Glycosylation and Etherification of the Side Chains of the Anticancer Drug Mitoxantrone. ChemMedChem.10:1528-1538

 

Faigenbloom L, Rubinstein ND, Kloog Y, Mayrose I, Pupko T, and Stein R (2015). Regulation of Alternative Splicing at the Single-Cell Level. Mol. Syst. Biol. 11:845

 

Menachem A, Makovski V, Bodner O, Pasmanik-Chor M, Stein R, Shomron N and Kloog Y (2016). Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy. Oncotarget, 15:12489-12504.

 

Schwartz H, Blacher E, Amer M, Livneh N, Klein A, Ben-Shushan D, Sofer S, Blazquez R, Barrantes-Freer A, Mueller M, Mueller-Decker K, Stein R, Tsarfaty G, Satchi-Fainaro R, Umansky V, Pukrop T and Erez N. (2016) Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation. Cancer Res. 76:4359-4371.

 

Blacher E, Ben Baruch B, Schwartz H, Mantsur E, Vaknine H, Erez N and Stein R. Stromal CD38 regulates progression of primary melanoma and generation of spontaneous metastasis. Under revision

 

Steinbuch KB, Raphael I. Benhamou RI, Levin L, Stein R and Fridman M. Increased Degree of Cis-Unsaturation in the Lipid Segment of Antifungal Cationic Amphiphiles Results in Selective Fungal Cell Disruption. Submitted 

 

 

*Corresponding author


 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
UI/UX Basch_Interactive