Prof. Shmuel Rozenblatt

מקרוביולוגיה מולקולרית בדימוס
Prof. Shmuel Rozenblatt
Phone: 03-6407508
External phone: 08-9316715
Fax: 03-6409407
Office: Green - Biotechnology, 134

CV

Education:

1976

Post-doctoral fellow; Massachusetts Institute of Technology, Cambridge, MA

1974 Ph.D.; Weizmann Institute
1969 M.Sc.; Bar-Ilan University
1966 B.Sc.; Bar-Ilan University

 

Academic Appointments:

1987-present Associate Professor; Department of Molecular Microbiology and Biotechnology, Tel Aviv University
1987 Director; The Oscar Lazar Laboratory of Genetic Engineering, Tel Aviv University
1983-1987 Associate Professor; Department of Virology; Weizmann Institute
1979-1983 Senior Scientist; Department of Virology; Weizmann Institute
1976-1979 Scientist; Department of Virology; Weizmann Institute

 

Other Appointments:

2009-2014 Visiting Scientist; Weizmann Institute of Science
2001 Visiting Scientist; Department of Genetics, Harvard Medical Schoo, Cambridge, MA
1993-4, 1995 Visiting Scientist; Viral Diseases Lab; National Institutes of Health, Bethesda, MD

 

Honors and Awards:

1988-1998 Oscar Lazar Fund (South Africa) 1979-1982 Charles H. Revson Career Development Chair
1988-1991 Ministry of Industry and Trade Grant 1978-1981 Israel Society Multiple Sclerosis Fellowships
1981-1984 Binational Science Foundation (with Dr. Bernard N. Fields) 1976-1979 Bat Sheva Rothschild Fellowship
1981-1984 Stifung Volkswagenwerk Fellowship (Germany), with Dr. Volkerter Meulen 1974 The Michael Landau Prize
1981-1982 Minerva Grant (Germany) 1974 Israel Cancer Association Bar Landsdorf Grant
1981-1982 Paul Godfrey Fund (Canada) 1974 Eleanor Roosevelt International Cancer Fellowship (Switzerland)
1981 Hirsch Prize (Israel Society for Microbiology)    

 

Research Interests

My lab seeks to develop a safe and economical measles vaccine for immunization of human beings and to obtain lifelong protection against measles.  During the last 15 years, one of the major efforts in my laboratory has concerned the measles virus, and the research goals are:  reconstitution of a new virus, molecularly tailored, for the purpose of future vaccination, and the eventual eradication of the virus.  We use recombinant DNA technology in the laboratory to pursue these goals.  To view movies related to the research, watch them here:  Video 1, Video 2, Video 3.

 

Recent Publications

Chuprin A, Gal H, Biron-Shental T, Biran A, Amiel A, Rozenblatt S, Krizhanovsky V. Cell fusion induced by ERVWE1 or measles virus causes cellular senescence. Genes Dev. 2013 Nov 1;27(21):2356-66. doi: 10.1101/gad.227512.113. PMID: 24186980

 

Yakubov E, Rechavi G, Rozenblatt S, Givol D. (2010) Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors. Biochem Biophys Res Commun.394(1):189-93.

 

Myers R, Greiner S, Harvey M, Soeffker D, Frenzke M, Abraham K, Shaw A, Rozenblatt S, Federspiel MJ, Russell SJ, Peng KW. (2005) Oncolytic activities of approved mumps and measles vaccines for therapy of ovarian cancer. Cancer Gene Ther,12(7):593-9.

 

Myers R, Frenzke M, Greiner S, Harvey M, Soeffker D, Abraham K, Shaw A, Rozenblatt S, Peng KW, Russell S. (2003) Comparative efficacy of fusogenic measles, mumps, and vaccinia vectors against ovarian cancer xenografts. MOLECULAR THERAPY 7 (5): 343 Part 2.

 

Zhu Y, Rota P, Wyatt L, Tamin A, Rozenblatt S, Lerche N, Moss B, Bellini W, McChesney M. (2000). Evaluation of recombinant vaccinia virus--measles vaccines in infant rhesus macaques with preexisting measles antibody. Virology. 276(1):202-213.

 

Stittelaar, K.J., Wyatt, L.S., de Swart, R.L., Vos, H.W., Groen, J., van Amerongen, G., van Binnendijk, R.S., Rozenblatt, S., Moss, B. and Osterhaus, A.D. (2000) Protective immunity in macaques vaccinated with a modified vaccinia virus Ankara-based measles virus vaccine in the presence of passively acquired antibodies. J Virol,74: 4236-4243.

 

Mokady, O., Loya, Y., Achituv, Y., Geffen, E., Graur, D., Rozenblatt, S. and Brickner, I. (1999) Speciation versus phenotypic plasticity in coral inhabiting barnacles: Darwin's observations in an ecological context. J Mol Evol,49:367-375.

 

Adar, R., Streicher, H., Rozenblatt, S. and Sharon, N. (1997) Synthesis of soybean agglutinin in bacterial and mammalian cells. Eur J Biochem,249: 684-689.

 

Wyatt, L.S., Moss, B. and Rozenblatt, S. (1995) Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cells. Virology,210: 202-205. 

 

 

Patents

Assay for Amoebas (DNA Probes) (T/7111) 
D. Mirelman, L.I. Garfinkel, M. Giladi, M. Huber, C. Gitler, M. Revel, and S. Rozenblatt

 

 

Figures

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