Dr. Adi Stern Grundland

מקרוביולוגיה מולקולרית סגל אקדמי בכיר
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Dr. Adi Stern Grundland
Phone: 03-6407508
Fax: 03-6409407

CV

Education: 

2003

B.Sc., Biology and Psychology, Tel-Aviv University

2003

Additional degree in Mathematics, Tel Aviv University

2005

M.Sc., Phylogenetic modelling, Tel Aviv University

2009

Ph.D., Viral Evolution, Tel Aviv University

2009-2011

Postdoctoral fellow, Microbial-phage co-evolution, Weizmann Institute

2011-2014

Postdoctoral fellow, experimental evolution in viruses, UCSF & UC Berkeley

 

 

Academic and Professional Awards:

2011

National Post-doctoral award for advancing women in science, Weizmann Institute of Science

2011

Post-doctoral fellowship, Rothschild foundation

2011

UNESCO L’Oreal prize for women in science

2010

Post-Doctoral scholarship, AXA Research Fund

2009

Post-Doctoral Prize, Clore Foundation

2008

Ph.D. excellence award, Wolf Foundation

2006 – 2007

Ph.D. Award for Women in Science, Israeli Ministry of Science

2006 – 2008

Ph.D. excellence scholarship, Yeshaia Horwitz Center for Complexity Science

2005, 2009

Ph.D. excellence scholarship, Tel-Aviv University Safra bioinformatics program

1999

B.Sc. Scholarship for excellent students in Mathematics 
Tel-Aviv University

 

Research Interests

Our research interests lie in the rapid evolution of viruses and their hosts. Viruses and hosts are at war: in order to survive, each side must constantly gain new weaponry. In our research lab we use a combination of computational biology, evolutionary theory, and experimental evolution in order to gain an understanding of this fascinating arms-race.

 

Publications

Stern, A. Bianco, S., Yeh, M.T., Wright, C., Butcher, K., Tang,. C., Nielsen, R., Andino, A. Costs and merits of mutational robustness in viruses. Cell Reports, (2014) In press 

 

Stern, A. CRISPR and RNA interference: similarities across immune systems. Physics of Life Reviews. pii: S1571-0645(13)00181-4. (2013)

 

Mick E., Stern A., Sorek R. Holding a grudge: Persisting anti-phage CRISPR immunity in multiple human gut microbiomes. RNA Biology, 10(5):1-7 (2013)

 

Mayrose, I., Stern, A., Burdelova, E., Sabo, Y., Laham-Karam, N., Zamostiano, R., Bacharach, E., Pupko, T. Synonymous site conservation in the HIV-1 genome. BMC Evolutionary Biology 13:164 (2013)

 

Stern, A., Mick, E., Tirosh, I., Sagi, O., Sorek, R. CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome. Genome Research, 22(10):1985-94 (2012)

 

Stern A., Sorek R. The phage-host arms race: shaping the evolution of microbes. Bioessays, 33(1): 43-51 (2011)

 

Stern, A., Keren, L., Amitai, G., Sorek, R.. Widespread targeting of self-DNA by the prokaryotic CRISPR immune system: gene regulation or auto-immunity? Trends in Genetics, 26(8):335-340 (2010)

 

Stern A., Mayrose I., Shaul S., Gophna U., Pupko T. An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes. Systematic Biology, 59(2): 212-225, (2010)

 

Penn O.* , Stern A.*, , Rubinstein N., Dutheil J., Bacharach E., Galtier N., Pupko T. 2008. Evolutionary modeling of rate shifts reveals specificity determinants in HIV-1 subtypes. PLoS Computational Biology. Nov;4(11):e1000214 (2008) *Authors contributed equally.

 

Sela N, Stern, A., Pupko, T., Ast, G. Transduplication resulted in the incorporation of two protein-coding sequences into the turmoil-1 transposable element of C. elegans. Biology Direct. Oct 8;3:41 (2008)

 

Cohen, O., Rubinstein, ND., Stern, A., Gophna, U., and Pupko, T. A likelihood framework to analyze phyletic patterns. Proceedings of The Royal Society of London Series B-Biological Sciences. Dec 27;363(1512):3903-11. (2008)

 

Stern, A., Doron-Faigenboim, A., Erez, E., Martz, E., Bacharach, E., Pupko, T. Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach. Nucleic Acids Research. 35: W506-W511 (2007)

 

Stern, A., Privman, E., Rasis, M., Lavi, S., Pupko, T. Evolution of the metazoan protein phosphatase 2C superfamily. J. Mol. Evol. 64(1):61-70, (2007)

 

Stern, A., Pupko, T. An Evolutionary Space-Time Model with Varying Among Site Dependencies. Mol. Biol. Evol. 23: 392-400 (2006)

 

Doron-Faigenboim, A.*, Stern, A.*, Mayrose, I., Bacharach, E., and Pupko, T. Selecton: a server for detecting evolutionary forces at a single amino-acid site. Bioinformatics. 21(9): 2101-2103 (2005) *Authors contributed equally.

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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