Prof. Uri Ashery

מחלקה לנוירוביולוגיה סגל אקדמי בכיר
Prof. Uri Ashery
Phone: 03-6409827
Fax: 03-6407643
Office: Sherman - Life Sciences

CV

Education:

1996-2001               Postdoctoral Research; Max Planck Institute- Gottingen, Germany

1990-1996               Ph.D.; Neurobiology, Hebrew University

1987-1990               B.Sc.; Biology and Chemistry, Hebrew University

 

Academic Appointments:

2013-current          Professor, Neurobiology department, Tel Aviv University, Tel Aviv

2009-2012               Associate Professor, Neurobiology department, Tel Aviv University, Tel Aviv

2005-2009               Senior Lecturer, Neurobiology department, Tel Aviv University, Tel Aviv

2001-2005               Lecturer; Neurobiology, Tel Aviv University

 

Other Experience and Professional Memberships

2018- current          Head, Sagol School of Neuroscience, Tel Aviv University

2017-  2018              Sabbatical Leave, Research associate, NINDS, NIH, Bethesda, MD

2011-  2017              Head, Sagol School of Neuroscience, Tel Aviv University

2010 - 2012              Chair, Department of Neurobiology, Tel Aviv University

2006 - 2011              Initiator and Head of the new Ph.D. program in Neurosciences, Tel Aviv University

2004 - 2007              Head of a B.Sc. program for brain studies, Tel Aviv University

Research Interests

Our main focus currently is on the following directions:

  • Investigating synaptic plasticity processes at the hippocampal mossy fiber synapses:
    • Investigating molecular mechanism of synaptic plasticity.
    • Elucidating mechanisms of cAMP dependent synaptic plasticity.
    • Correlating between synaptic plasticity to learning and memory processes.
  • Elucidating the mitigating effects of hyperbaric oxygen treatment (HBOT) in Alzheimer's disease (AD) mouse models:
    • Investigating the molecular and cellular mechanisms that are regulated following HBOT in AD mouse models.
    • Exploring the physiological effect of HBOT on synaptic activity and plasticity and on blood flow.
    •  
  • Identifying early biomarkers for Parkinson’s disease (PD):
    • Characterizing early steps in alpha synuclein aggregation.
    • Investigating the effect of alpha synuclein aggregation on neuronal activity.

We employ a wide range of methods including: Electrophysiology, Slice recording, Total Internal Reflection Fluorescence (TIRF), Super resolution microscopy (STORM, STED), Fluorescence Resonance Energy Transfer (FRET), Molecular biology, Model simulation, Multi electrode array (MEA) recording, Immunohistochemistry and Behavioral tests.

Recent Publications

Selected Publications

 

  • Perets N, Betzer O, Shapira R, Brenstein S, Angel A, Sadan T, et al. Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders. Nano Lett. 2019 Feb 27;acs.nanolett.8b04148.
  • Shapira R, Solomon B, Efrati S, Frenkel D, Ashery U. Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation. Neurobiol Aging. 2018 Feb;62:105–19.
  • Michaeli L, Gottfried I, Bykhovskaia M, Ashery U. Phosphatidylinositol (4, 5)-bisphosphate targets double C2 domain protein B to the plasma membrane. Traffic. 2017 Dec;18(12):825–39.
  • Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, et al. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn. J Neurosci. 2016;36(44):11208–22.
  • Ben-Simon Y, Rodenas-Ruano A, Alviña K, Lam AD, Stuenkel EL, Castillo PE, et al. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity. Cell Rep. 2015 Jul 21;12(3):396–404.
  • Lavi A, Perez O, Ashery U. Shaping Neuronal Network Activity by Presynaptic Mechanisms. Gutkin BS, editor. PLoS Comput Biol. 2015 Sep 15;11(9):e1004438.
  • Ehmann N, van de Linde S, Alon A, Ljaschenko D, Keung XZ, Holm T, et al. Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Nat Commun. 2014 Aug 18;5(1):4650.
  • Barak B, Okun E, Ben-Simon Y, Lavi A, Shapira R, Madar R, et al. Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory. Neuromolecular Med. 2013 Jun 22;15(2):351–63.
  • Lipstein N, Sakaba T, Cooper BH, Lin K-H, Strenzke N, Ashery U, et al. Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling. Neuron. 2013 Jul 10;79(1):82–96.
  • Bar-On D, Wolter S, van de Linde S, Heilemann M, Nudelman G, Nachliel E, et al. Super-resolution imaging reveals the internal architecture of nano-sized syntaxin clusters. J Biol Chem. 2012 Aug 3;287(32):27158–67.

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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